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Peptide record

TPDB13589

Antibacterial Anticancer Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB13589
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RFRRFRLPFRRIHPPPFVRIHPPPFYRRFL
Physicochemical Analysis
C193H289N61O32
ANDCEQGKMSTW
R
3975.81
12.94
11
0
12
+9
2.97
-0.727
61.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
37.48
1
Residue Composition
number
0
A
9
R
0
N
0
D
0
C
0
E
0
Q
0
G
2
H
2
I
2
L
0
K
0
M
6
F
7
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 2 L: 2 K: 0 M: 0 F: 6 P: 7 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
30
C193H289N61O32
3975.81
12.94
+9
2.97
-0.727
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
18.3±4.1 µM
Cytotoxic
50% Cytotoxicity | 18.3±4.1 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs. | Front Cell Infect Microbiol | 2020
Evidence 2 Activity

Activity

<5% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
<5% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs. | Front Cell Infect Microbiol | 2020
Evidence 3 Activity

Activity

IC50
Toxicity
18.3
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: <5% Hemolysis=64 µM | Cytotoxicity: Human PBMC: IC50=18.3 ± 4.1 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Cell Infect Microbiol. 2020 Oct 19 10:552905.