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Peptide record

TPDB13574

Antibacterial Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB13574
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ALWKSILKNVGKAAGKAVLNAVTDMVNQ
Physicochemical Analysis
C131H223N37O37S1
RCEHFPY
A
2940.50
10.55
4
1
15
+3
2.68
0.261
115.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
187.04
6
Residue Composition
number
5
A
0
R
3
N
1
D
0
C
0
E
1
Q
2
G
0
H
1
I
3
L
4
K
1
M
0
F
0
P
1
S
1
T
1
W
0
Y
4
V
Amino Acid Distribution
A: 5 R: 0 N: 3 D: 1 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 1 L: 3 K: 4 M: 1 F: 0 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 4
Chemical Descriptors
28
C131H223N37O37S1
2940.50
10.55
+3
2.68
0.261
Evidence Records 3 records
Evidence 1 Activity

Activity

20% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
20% Hemolysis | 64 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Design of N-Terminal Derivatives from a Novel Dermaseptin Exhibiting Broad-Spectrum Antimicrobial Activity against Isolates from Cystic Fibrosis Patients. | Biomolecules | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
50% Hemolysis | 128 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Design of N-Terminal Derivatives from a Novel Dermaseptin Exhibiting Broad-Spectrum Antimicrobial Activity against Isolates from Cystic Fibrosis Patients. | Biomolecules | 2019
Evidence 3 Activity

Activity

90% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
90% Hemolysis | 256 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Design of N-Terminal Derivatives from a Novel Dermaseptin Exhibiting Broad-Spectrum Antimicrobial Activity against Isolates from Cystic Fibrosis Patients. | Biomolecules | 2019