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Peptide record

TPDB13571

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB13571
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 28-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
KFFKKFFKKFFKKFFKKFFKKFFKKFFK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C210H296N42O29
ARNDCEQGHILMPSTWYV
KF
3872.93
11.62
14
0
14
+14
1.29
-0.550
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
14
K
0
M
14
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 14 M: 0 F: 14 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
28 reviewed residue count
C210H296N42O29 sequence-only estimate (linear, free termini)
3872.93 sequence-only estimate (linear, free termini)
11.62 sequence-only estimate (linear, free termini)
+14 sequence-only estimate (linear, free termini)
1.29 sequence-only estimate (linear, free termini)
-0.550 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
12 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 12 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Periodic antimicrobial peptides. | PATENT US 7091185 B2 | 2006
Evidence 2 Activity

Activity

100% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
100% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Periodic antimicrobial peptides. | PATENT US 7091185 B2 | 2006
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis