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Peptide record

TPDB13569

Antibacterial Antifungal Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB13569
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IHHIHHHIHHIHHHIHHIHHHIHHIHHH
Physicochemical Analysis
C168H230N68O29
ARNDCEQGLKMFPSTWYV
H
3666.11
8.51
20
0
8
+2
16.72
-1.000
111.43
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
20
H
8
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 20 I: 8 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
28
C168H230N68O29
3666.11
8.51
+2
16.72
-1.000
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
10% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Highly Stabilized ?-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition. | ACS Appl Mater Interfaces | 2019
Evidence 2 Activity

Activity

10% Killing
Toxicity
>128 µM
Cytotoxic
10% Killing | >128 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Highly Stabilized ?-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition. | ACS Appl Mater Interfaces | 2019
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
5 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31199117] 5% hemolysis at 63µM, 8% hemolysis at 128µM against human red blood cells | Cytotoxicity: [Ref.31199117] ①The cell viability of HEK293T cells induced by 2IH4 is at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 µM at pH 7.4, while that induced by Melittin is 47.2%, 1.7%, 1.9%, 0.6%, 0.6%, 0.6% and 1.7% at 2, 4, 8, 16, 32, 64 and 128 µM. ②The cell viability of HEK293T cells induced by 2IH4 is 103.7%, 103.7%, 104.8%, 103.4%, 105.3%, 94.9% and 57.9% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 µM at pH 6.0, while that induced by Melittin is 43.8%, 3.4%, 3.4%, 0%, 2.2%, 0% and 1.1% at 2, 4, 8, 16, 32, 64 and 128 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Appl Mater Interfaces. 2019 Jun 26 11(25):22113-22128. doi: 10.1021/acsami.9b04654. Epub 2019 Jun 14.