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Peptide record

TPDB13568

Antibacterial Anticancer Antifungal Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB13568
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP CAFPdb dbAMP ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
ALWKTLLKHVGKAAGKAALNAVTDMVNQ
Physicochemical Analysis
C132H222N38O36S1
RCEIFPSY
A
2949.51
10.55
5
1
15
+3
2.74
0.164
108.21
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
186.47
5
Residue Composition
number
6
A
0
R
2
N
1
D
0
C
0
E
1
Q
2
G
1
H
0
I
4
L
4
K
1
M
0
F
0
P
0
S
2
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 6 R: 0 N: 2 D: 1 C: 0 E: 0 Q: 1 G: 2 H: 1 I: 0 L: 4 K: 4 M: 1 F: 0 P: 0 S: 0 T: 2 W: 1 Y: 0 V: 3
Chemical Descriptors
28
C132H222N38O36S1
2949.51
10.55
+3
2.74
0.164
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4-8 µM

Target

Staphylococcus aureus ATCC 12600 MRSA ATCC BAA-1720

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against S. aureus ATCC 12600 MRSA ATCC BAA-1720 (MIC 4-8 uM), E. faecalis ATCC 29212 (MIC 32 uM), E. coli ATCC 11755 (MIC 8 uM), P. aeruginosa ATCC 27
Evidence 2 Activity

Activity

MIC
Antibacterial
32 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP

Other

active against S. aureus ATCC 12600 MRSA ATCC BAA-1720 (MIC 4-8 uM), E. faecalis ATCC 29212 (MIC 32 uM), E. coli ATCC 11755 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), and C. albicans ATC
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µM

Target

Escherichia coli ATCC 11755

Source & Reference

dbAMP

Other

S. aureus ATCC 12600 MRSA ATCC BAA-1720 (MIC 4-8 uM), E. faecalis ATCC 29212 (MIC 32 uM), E. coli ATCC 11755 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), and C. albicans ATCC 10231 (MIC 4 uM). MBC are the
Evidence 4 Activity

Activity

MIC
Antibacterial
16 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

BAA-1720 (MIC 4-8 uM), E. faecalis ATCC 29212 (MIC 32 uM), E. coli ATCC 11755 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), and C. albicans ATCC 10231 (MIC 4 uM). MBC are the same or 2-fold higher, indicating bac
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP

Other

212 (MIC 32 uM), E. coli ATCC 11755 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), and C. albicans ATCC 10231 (MIC 4 uM). MBC are the same or 2-fold higher, indicating bactericidal. In addition, it inhibited fo
Evidence 6 Activity

Activity

MIC
Antifungal
4-8 µM

Target

Staphylococcus aureus ATCC 12600 MRSA ATCC BAA-1720

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against S. aureus ATCC 12600 MRSA ATCC BAA-1720 (MIC 4-8 uM), E. faecalis ATCC 29212 (MIC 32 uM), E. coli ATCC 11755 (MIC 8 uM), P. aeruginosa ATCC 27
Evidence 7 Activity

Activity

MIC
Antifungal
32 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP CAFPdb

Other

active against S. aureus ATCC 12600 MRSA ATCC BAA-1720 (MIC 4-8 uM), E. faecalis ATCC 29212 (MIC 32 uM), E. coli ATCC 11755 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), and C. albicans ATC
Evidence 8 Activity

Activity

MIC
Antifungal
8 µM

Target

Escherichia coli ATCC 11755

Source & Reference

dbAMP CAFPdb

Other

S. aureus ATCC 12600 MRSA ATCC BAA-1720 (MIC 4-8 uM), E. faecalis ATCC 29212 (MIC 32 uM), E. coli ATCC 11755 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), and C. albicans ATCC 10231 (MIC 4 uM). MBC are the
Evidence 9 Activity

Activity

MIC
Antifungal
16 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb

Other

BAA-1720 (MIC 4-8 uM), E. faecalis ATCC 29212 (MIC 32 uM), E. coli ATCC 11755 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), and C. albicans ATCC 10231 (MIC 4 uM). MBC are the same or 2-fold higher, indicating bac
Evidence 10 Activity

Activity

MIC
Antifungal
4 µM

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP CAFPdb

Other

212 (MIC 32 uM), E. coli ATCC 11755 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), and C. albicans ATCC 10231 (MIC 4 uM). MBC are the same or 2-fold higher, indicating bactericidal. In addition, it inhibited fo
Evidence 11 Activity

Activity

50% Cell death
Toxicity
460 µM
Cytotoxic
50% Cell death | 460 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Evaluating the Bioactivity of a Novel Antimicrobial and Anticancer Peptide, Dermaseptin-PS4(Der-PS4), from the Skin Secretion of Phyllomedusa sauvagii. | Molecules | 2019
Evidence 12 Activity

Activity

8% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
8% Hemolysis | 32 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Evaluating the Bioactivity of a Novel Antimicrobial and Anticancer Peptide, Dermaseptin-PS4(Der-PS4), from the Skin Secretion of Phyllomedusa sauvagii. | Molecules | 2019
Evidence 13 Activity

Activity

18% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
18% Hemolysis | 64 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Evaluating the Bioactivity of a Novel Antimicrobial and Anticancer Peptide, Dermaseptin-PS4(Der-PS4), from the Skin Secretion of Phyllomedusa sauvagii. | Molecules | 2019
Evidence 14 Activity

Activity

50% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
50% Hemolysis | 128 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Evaluating the Bioactivity of a Novel Antimicrobial and Anticancer Peptide, Dermaseptin-PS4(Der-PS4), from the Skin Secretion of Phyllomedusa sauvagii. | Molecules | 2019