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Peptide record

TPDB13566

Figainin 2 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB13566
Figainin 2
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb dbAMP dbAMP 3.0 AI4AVP DRAVP 2.0 PD_Hemolysis ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
FLGAILKIGHALAKTVLPMVTNAFKPKQ
Physicochemical Analysis
C142H236N36O33S1
RDCESWY
ALK
3007.72
11.00
5
0
15
+4
1.23
0.575
118.57
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
4
Residue Composition
number
4
A
0
R
1
N
0
D
0
C
0
E
1
Q
2
G
1
H
2
I
4
L
4
K
1
M
2
F
2
P
0
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 1 I: 2 L: 4 K: 4 M: 1 F: 2 P: 2 S: 0 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
28
C142H236N36O33S1
3007.72
11.00
+4
1.23
0.575
Free
L
Linear
Free
Antimicrobial and Anticancer
Boana raniceps
Evidence Records 24 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4-8 µM

Target

E. casseliflavus ATCC 700327

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
t Gram+ bacteria S. aureus ATCC 25923, E. faecalis ATCC 29212, S. epidermidis ATCC 12228, E. casseliflavus ATCC 700327 (MIC 4-8 uM). Gram- E. coli ATCC 25922, K. pneumoniae ATCC 13883 (MIC 8 uM), K. pneumoniae carbapanema
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP

Other

dermidis ATCC 12228, E. casseliflavus ATCC 700327 (MIC 4-8 uM). Gram- E. coli ATCC 25922, K. pneumoniae ATCC 13883 (MIC 8 uM), K. pneumoniae carbapanemase (KPC) MR, P. aeruginosa ATCC 27853 (MIC 16-32 uM). Antiparas
Evidence 3 Activity

Activity

MIC
Antibacterial
16-32 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

li ATCC 25922, K. pneumoniae ATCC 13883 (MIC 8 uM), K. pneumoniae carbapanemase (KPC) MR, P. aeruginosa ATCC 27853 (MIC 16-32 uM). Antiparasitic against Trypanosoma epimastigotes form T. cruzi (MIC 6.3 uM). The peptide
Evidence 4 Activity

Activity

MIC
Antibacterial
6.3 µM

Target

T. cruzi

Source & Reference

dbAMP

Other

eruginosa ATCC 27853 (MIC 16-32 uM). Antiparasitic against Trypanosoma epimastigotes form T. cruzi (MIC 6.3 uM). The peptide also inhibits cancer cell proliferation (IC50 = 12.8 uM for B16F10 murine me
Evidence 5 Activity

Activity

IC50
IC50 = 12.8 µM
Anticancer
12.8 µM

Target

Skin Cancer
B16-F10
Skin

Assay & Model

MTT assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2020

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 6 Activity

Activity

IC50
IC50= 15.3 µM
Anticancer
15.3 µM

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2020
Evidence 7 Activity

Activity

MIC
Antifungal
4-8 µM

Target

E. casseliflavus ATCC 700327

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
t Gram+ bacteria S. aureus ATCC 25923, E. faecalis ATCC 29212, S. epidermidis ATCC 12228, E. casseliflavus ATCC 700327 (MIC 4-8 uM). Gram- E. coli ATCC 25922, K. pneumoniae ATCC 13883 (MIC 8 uM), K. pneumoniae carbapanema
Evidence 8 Activity

Activity

MIC
Antifungal
8 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP CAFPdb Antifungipept

Other

dermidis ATCC 12228, E. casseliflavus ATCC 700327 (MIC 4-8 uM). Gram- E. coli ATCC 25922, K. pneumoniae ATCC 13883 (MIC 8 uM), K. pneumoniae carbapanemase (KPC) MR, P. aeruginosa ATCC 27853 (MIC 16-32 uM). Antiparas
Evidence 9 Activity

Activity

MIC
Antifungal
16-32 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

li ATCC 25922, K. pneumoniae ATCC 13883 (MIC 8 uM), K. pneumoniae carbapanemase (KPC) MR, P. aeruginosa ATCC 27853 (MIC 16-32 uM). Antiparasitic against Trypanosoma epimastigotes form T. cruzi (MIC 6.3 uM). The peptide
Evidence 10 Activity

Activity

MIC
Antifungal
6.3 µM

Target

T. cruzi

Source & Reference

dbAMP CAFPdb Antifungipept

Other

eruginosa ATCC 27853 (MIC 16-32 uM). Antiparasitic against Trypanosoma epimastigotes form T. cruzi (MIC 6.3 uM). The peptide also inhibits cancer cell proliferation (IC50 = 12.8 uM for B16F10 murine me
Evidence 11 Activity

Activity

MIC
Antiparasitic
4-8 µM

Target

E. casseliflavus ATCC 700327

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
t Gram+ bacteria S. aureus ATCC 25923, E. faecalis ATCC 29212, S. epidermidis ATCC 12228, E. casseliflavus ATCC 700327 (MIC 4-8 uM). Gram- E. coli ATCC 25922, K. pneumoniae ATCC 13883 (MIC 8 uM), K. pneumoniae carbapanema
Evidence 12 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP 3.0

Other

dermidis ATCC 12228, E. casseliflavus ATCC 700327 (MIC 4-8 uM). Gram- E. coli ATCC 25922, K. pneumoniae ATCC 13883 (MIC 8 uM), K. pneumoniae carbapanemase (KPC) MR, P. aeruginosa ATCC 27853 (MIC 16-32 uM). Antiparas
Evidence 13 Activity

Activity

MIC
Antiparasitic
16-32 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0

Other

li ATCC 25922, K. pneumoniae ATCC 13883 (MIC 8 uM), K. pneumoniae carbapanemase (KPC) MR, P. aeruginosa ATCC 27853 (MIC 16-32 uM). Antiparasitic against Trypanosoma epimastigotes form T. cruzi (MIC 6.3 uM). The peptide
Evidence 14 Activity

Activity

MIC
Antiparasitic
6.3 µM

Target

T. cruzi

Source & Reference

dbAMP 3.0

Other

eruginosa ATCC 27853 (MIC 16-32 uM). Antiparasitic against Trypanosoma epimastigotes form T. cruzi (MIC 6.3 uM). The peptide also inhibits cancer cell proliferation (IC50 = 12.8 uM for B16F10 murine me
Evidence 15 Activity

Activity

MIC
Antiviral
4-8 µM

Target

E. casseliflavus ATCC 700327

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
t Gram+ bacteria S. aureus ATCC 25923, E. faecalis ATCC 29212, S. epidermidis ATCC 12228, E. casseliflavus ATCC 700327 (MIC 4-8 uM). Gram- E. coli ATCC 25922, K. pneumoniae ATCC 13883 (MIC 8 uM), K. pneumoniae carbapanema
Evidence 16 Activity

Activity

MIC
Antiviral
8 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

dermidis ATCC 12228, E. casseliflavus ATCC 700327 (MIC 4-8 uM). Gram- E. coli ATCC 25922, K. pneumoniae ATCC 13883 (MIC 8 uM), K. pneumoniae carbapanemase (KPC) MR, P. aeruginosa ATCC 27853 (MIC 16-32 uM). Antiparas
Evidence 17 Activity

Activity

MIC
Antiviral
16-32 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

li ATCC 25922, K. pneumoniae ATCC 13883 (MIC 8 uM), K. pneumoniae carbapanemase (KPC) MR, P. aeruginosa ATCC 27853 (MIC 16-32 uM). Antiparasitic against Trypanosoma epimastigotes form T. cruzi (MIC 6.3 uM). The peptide
Evidence 18 Activity

Activity

MIC
Antiviral
6.3 µM

Target

T. cruzi

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

eruginosa ATCC 27853 (MIC 16-32 uM). Antiparasitic against Trypanosoma epimastigotes form T. cruzi (MIC 6.3 uM). The peptide also inhibits cancer cell proliferation (IC50 = 12.8 uM for B16F10 murine me
Evidence 19 Activity

Activity

9% Hemolysis
Toxicity
16 µM
Hemolytic Cytotoxic
9% Hemolysis | 16 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Biological Properties of a Novel Multifunctional Host Defense Peptide from the Skin Secretion of the Chaco Tree Frog, Boana raniceps. | Biomolecules | 2020
Evidence 20 Activity

Activity

23% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
23% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Biological Properties of a Novel Multifunctional Host Defense Peptide from the Skin Secretion of the Chaco Tree Frog, Boana raniceps. | Biomolecules | 2020
Evidence 21 Activity

Activity

50% Hemolysis
Toxicity
48.9 µM
Hemolytic Cytotoxic
50% Hemolysis | 48.9 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Biological Properties of a Novel Multifunctional Host Defense Peptide from the Skin Secretion of the Chaco Tree Frog, Boana raniceps. | Biomolecules | 2020
Evidence 22 Activity

Activity

22% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
22% Hemolysis | 80 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
All-hydrocarbon stapling enables improvement of antimicrobial activity and proteolytic stability of peptide Figainin 2. | J Pept Sci | 2024
Evidence 23 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.32443921]No cytotoxicity against noninfected Huh7 cells at concentrations as high as 25 µM.

Source & Reference

NA
DRAMP
Biomolecules. 2020 May 20 10(5):790.
Evidence 24 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis