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Peptide record

TPDB13564

Antibacterial Anticancer Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB13564
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RFRLPFRRPWPIRIHPPPFYPWPFRRFL
Physicochemical Analysis
C188H267N53O30
ANDCEQGKMSTV
P
3749.53
12.80
8
0
12
+7
-1.80
-0.714
55.71
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
12490
333.11
1
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
2
I
2
L
0
K
0
M
5
F
8
P
0
S
0
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 2 L: 2 K: 0 M: 0 F: 5 P: 8 S: 0 T: 0 W: 2 Y: 1 V: 0
Chemical Descriptors
28
C188H267N53O30
3749.53
12.80
+7
-1.80
-0.714
Evidence Records 5 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
20.2±4.5 µM
Cytotoxic
50% Cytotoxicity | 20.2±4.5 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs. | Front Cell Infect Microbiol | 2020
Evidence 2 Activity

Activity

7±2% Hemolysis
Toxicity
16 µM
Hemolytic Cytotoxic
7±2% Hemolysis | 16 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs. | Front Cell Infect Microbiol | 2020
Evidence 3 Activity

Activity

19±2% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
19±2% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs. | Front Cell Infect Microbiol | 2020
Evidence 4 Activity

Activity

25±2% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
25±2% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs. | Front Cell Infect Microbiol | 2020
Evidence 5 Activity

Activity

IC50
Toxicity
20.2
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 25 ± 2% Hemolysis=64 µM | Cytotoxicity: Human PBMC: IC50=20.2 ± 4.5 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Cell Infect Microbiol. 2020 Oct 19 10:552905.