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Peptide record

TPDB13563

Antibacterial Antifungal Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB13563
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
ASWKVFLKNIGKAAGKAVLNSVTDMVNQ
Physicochemical Analysis
C134H221N37O38S1
RCEHPY
AKV
2990.51
10.55
4
1
14
+3
2.41
0.132
97.50
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
183.91
7
Residue Composition
number
4
A
0
R
3
N
1
D
0
C
0
E
1
Q
2
G
0
H
1
I
2
L
4
K
1
M
1
F
0
P
2
S
1
T
1
W
0
Y
4
V
Amino Acid Distribution
A: 4 R: 0 N: 3 D: 1 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 1 L: 2 K: 4 M: 1 F: 1 P: 0 S: 2 T: 1 W: 1 Y: 0 V: 4
Chemical Descriptors
28
C134H221N37O38S1
2990.51
10.55
+3
2.41
0.132
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.68 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli ATCC 25922 (MIC 2.68 uM), S. aureus ATCC 25923 (MIC 2.68 uM), K. pneumoniae (MIC 10.7 uM) and C. albicans (MIC 10.
Evidence 2 Activity

Activity

MIC
Antibacterial
2.68 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Active against E. coli ATCC 25922 (MIC 2.68 uM), S. aureus ATCC 25923 (MIC 2.68 uM), K. pneumoniae (MIC 10.7 uM) and C. albicans (MIC 10.7 uM). Parasites: P. falciparum NF54
Evidence 3 Activity

Activity

MIC
Antibacterial
10.7 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP

Other

Active against E. coli ATCC 25922 (MIC 2.68 uM), S. aureus ATCC 25923 (MIC 2.68 uM), K. pneumoniae (MIC 10.7 uM) and C. albicans (MIC 10.7 uM). Parasites: P. falciparum NF54 (IC50 12.06 uM) or TM90C2B (
Evidence 4 Activity

Activity

MIC
Antibacterial
10.7 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

25922 (MIC 2.68 uM), S. aureus ATCC 25923 (MIC 2.68 uM), K. pneumoniae (MIC 10.7 uM) and C. albicans (MIC 10.7 uM). Parasites: P. falciparum NF54 (IC50 12.06 uM) or TM90C2B (IC50 15.34 uM), L. Mexicana (I
Evidence 5 Activity

Activity

IC50
Antibacterial
12.06 µM

Target

P. falciparum NF54

Source & Reference

dbAMP

Other

5923 (MIC 2.68 uM), K. pneumoniae (MIC 10.7 uM) and C. albicans (MIC 10.7 uM). Parasites: P. falciparum NF54 (IC50 12.06 uM) or TM90C2B (IC50 15.34 uM), L. Mexicana (IC50 0.61 uM) ( Proaño-Bolaños et al., 2024 . Up
Evidence 6 Activity

Activity

IC50
Antibacterial
0.61 µM

Target

L. Mexicana

Source & Reference

dbAMP

Other

(MIC 10.7 uM). Parasites: P. falciparum NF54 (IC50 12.06 uM) or TM90C2B (IC50 15.34 uM), L. Mexicana (IC50 0.61 uM) ( Proaño-Bolaños et al., 2024 . Updated 7/2024
Evidence 7 Activity

Activity

MIC
Antifungal
2.68 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli ATCC 25922 (MIC 2.68 uM), S. aureus ATCC 25923 (MIC 2.68 uM), K. pneumoniae (MIC 10.7 uM) and C. albicans (MIC 10.
Evidence 8 Activity

Activity

MIC
Antifungal
2.68 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 (MIC 2.68 uM), S. aureus ATCC 25923 (MIC 2.68 uM), K. pneumoniae (MIC 10.7 uM) and C. albicans (MIC 10.7 uM). Parasites: P. falciparum NF54
Evidence 9 Activity

Activity

MIC
Antifungal
10.7 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 (MIC 2.68 uM), S. aureus ATCC 25923 (MIC 2.68 uM), K. pneumoniae (MIC 10.7 uM) and C. albicans (MIC 10.7 uM). Parasites: P. falciparum NF54 (IC50 12.06 uM) or TM90C2B (
Evidence 10 Activity

Activity

MIC
Antifungal
10.7 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

25922 (MIC 2.68 uM), S. aureus ATCC 25923 (MIC 2.68 uM), K. pneumoniae (MIC 10.7 uM) and C. albicans (MIC 10.7 uM). Parasites: P. falciparum NF54 (IC50 12.06 uM) or TM90C2B (IC50 15.34 uM), L. Mexicana (I
Evidence 11 Activity

Activity

IC50
Antifungal
12.06 µM

Target

P. falciparum NF54

Source & Reference

dbAMP CAFPdb Antifungipept

Other

5923 (MIC 2.68 uM), K. pneumoniae (MIC 10.7 uM) and C. albicans (MIC 10.7 uM). Parasites: P. falciparum NF54 (IC50 12.06 uM) or TM90C2B (IC50 15.34 uM), L. Mexicana (IC50 0.61 uM) ( Proaño-Bolaños et al., 2024 . Up
Evidence 12 Activity

Activity

IC50
Antifungal
0.61 µM

Target

L. Mexicana

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 10.7 uM). Parasites: P. falciparum NF54 (IC50 12.06 uM) or TM90C2B (IC50 15.34 uM), L. Mexicana (IC50 0.61 uM) ( Proaño-Bolaños et al., 2024 . Updated 7/2024
Evidence 13 Activity

Activity

0% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
0% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Unravelling the Skin Secretion Peptides of the Gliding Leaf Frog, Agalychnis spurrelli (Hylidae) | Biomolecules | 2019
Evidence 14 Activity

Activity

20% Hemolysis
Toxicity
512 µM
Hemolytic Cytotoxic
20% Hemolysis | 512 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Unravelling the Skin Secretion Peptides of the Gliding Leaf Frog, Agalychnis spurrelli (Hylidae) | Biomolecules | 2019