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Peptide record

TPDB13559

Antibacterial Antifungal Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB13559
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
GLWKSLFKNVGKAAGKAALNAVTDMVNQ
Physicochemical Analysis
C131H215N37O37S1
RCEHIPY
A
2932.43
10.55
4
1
14
+3
1.80
0.036
90.71
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
187.56
6
Residue Composition
number
5
A
0
R
3
N
1
D
0
C
0
E
1
Q
3
G
0
H
0
I
3
L
4
K
1
M
1
F
0
P
1
S
1
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 5 R: 0 N: 3 D: 1 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 3 K: 4 M: 1 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 3
Chemical Descriptors
28
C131H215N37O37S1
2932.43
10.55
+3
1.80
0.036
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Staphylococcus aureus NCTC 10788

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against S. aureus NCTC 10788 (MIC 16 ug/ml), MRSA NCTC 12493 (MIC 64 ug/ml), MRSA (ATCC 43300) (MIC 32 ug/ml), C. albicans NCYC 1467
Evidence 2 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

Candida albicans NCYC 1467

Source & Reference

dbAMP

Other

C 10788 (MIC 16 ug/ml), MRSA NCTC 12493 (MIC 64 ug/ml), MRSA (ATCC 43300) (MIC 32 ug/ml), C. albicans NCYC 1467 (MIC 32 ug/ml), E. coli (NCTC 10418) (MIC 16 ug/ml), and P. aeruginosa (ATCC 27853) (MIC 64 ug/ml). Also
Evidence 3 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Staphylococcus aureus NCTC 10788

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against S. aureus NCTC 10788 (MIC 16 ug/ml), MRSA NCTC 12493 (MIC 64 ug/ml), MRSA (ATCC 43300) (MIC 32 ug/ml), C. albicans NCYC 1467
Evidence 4 Activity

Activity

MIC
Antifungal
32 µg/mL

Target

Candida albicans NCYC 1467

Source & Reference

dbAMP CAFPdb

Other

C 10788 (MIC 16 ug/ml), MRSA NCTC 12493 (MIC 64 ug/ml), MRSA (ATCC 43300) (MIC 32 ug/ml), C. albicans NCYC 1467 (MIC 32 ug/ml), E. coli (NCTC 10418) (MIC 16 ug/ml), and P. aeruginosa (ATCC 27853) (MIC 64 ug/ml). Also
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
>512 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >512 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Identification of New Dermaseptins With Self-Assembly Tendency: Membrane Disruption, Biofilm Eradication, and Infected Wound Healing Efficacy. | Acta Biomater | 2020