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Peptide record

TPDB13558

Antibacterial Antifungal Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB13558
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
ALWKTLLKNVGKAAGKAVLNAVTDMVNQ
Physicochemical Analysis
C132H225N37O37S1
RCEHIFPSY
A
2954.52
10.55
4
1
15
+3
2.44
0.239
115.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
186.16
6
Residue Composition
number
5
A
0
R
3
N
1
D
0
C
0
E
1
Q
2
G
0
H
0
I
4
L
4
K
1
M
0
F
0
P
0
S
2
T
1
W
0
Y
4
V
Amino Acid Distribution
A: 5 R: 0 N: 3 D: 1 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 4 K: 4 M: 1 F: 0 P: 0 S: 0 T: 2 W: 1 Y: 0 V: 4
Chemical Descriptors
28
C132H225N37O37S1
2954.52
10.55
+3
2.44
0.239
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Staphylococcus aureus NCTC 10788

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against S. aureus NCTC 10788 (MIC 8 ug/ml), MRSA NCTC 12493 (MIC 16 ug/ml), MRSA (ATCC 43300) (MIC 8 ug/ml), C. albicans NCYC 1467 (
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Candida albicans NCYC 1467

Source & Reference

dbAMP

Other

CTC 10788 (MIC 8 ug/ml), MRSA NCTC 12493 (MIC 16 ug/ml), MRSA (ATCC 43300) (MIC 8 ug/ml), C. albicans NCYC 1467 (MIC 16 ug/ml), E. coli (NCTC 10418) (MIC 8 ug/ml), and P. aeruginosa (ATCC 27853) (MIC 16 ug/ml). Also
Evidence 3 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Staphylococcus aureus NCTC 10788

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against S. aureus NCTC 10788 (MIC 8 ug/ml), MRSA NCTC 12493 (MIC 16 ug/ml), MRSA (ATCC 43300) (MIC 8 ug/ml), C. albicans NCYC 1467 (
Evidence 4 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Candida albicans NCYC 1467

Source & Reference

dbAMP CAFPdb

Other

CTC 10788 (MIC 8 ug/ml), MRSA NCTC 12493 (MIC 16 ug/ml), MRSA (ATCC 43300) (MIC 8 ug/ml), C. albicans NCYC 1467 (MIC 16 ug/ml), E. coli (NCTC 10418) (MIC 8 ug/ml), and P. aeruginosa (ATCC 27853) (MIC 16 ug/ml). Also
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
210.7 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 210.7 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Identification of New Dermaseptins With Self-Assembly Tendency: Membrane Disruption, Biofilm Eradication, and Infected Wound Healing Efficacy. | Acta Biomater | 2020