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Peptide record

TPDB13550

Antibacterial Anticancer Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB13550
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RFRRLRWKTRWRLKKICYCRRRFCVCV
Physicochemical Analysis
C165H271N59O30S4
ANDEQGHMPS
R
3689.58
12.12
12
0
10
+12
1.25
-0.737
64.81
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
12740
345.30
6
Residue Composition
number
0
A
9
R
0
N
0
D
4
C
0
E
0
Q
0
G
0
H
1
I
2
L
3
K
0
M
2
F
0
P
0
S
1
T
2
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 3 M: 0 F: 2 P: 0 S: 0 T: 1 W: 2 Y: 1 V: 2
Chemical Descriptors
27
C165H271N59O30S4
3689.58
12.12
+12
1.25
-0.737
Evidence Records 2 records
Evidence 1 Activity

Activity

59.28% Hemolysis
Toxicity
294.3 µg/mL
Hemolytic Cytotoxic
59.28% Hemolysis | 294.3 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of cell selectivity, physiological stability and endotoxin neutralization capabilities of ?-helix-based peptide amphiphiles. | Biomaterials | 2015
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
0.5 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.25818457] 0.5% hemolysis at 1.1 mg/L , 2% hemolysis at 2.3 mg/L , 10% hemolysis at 4.6 mg/L , 23% hemolysis at 9.2 mg/L , 30% hemolysis at 18.4 mg/L , 45% hemolysis at 36.8mg/L , 46% hemolysis at 73.6 mg/L , 47% hemolysis at 147.1 mg/L , 50% hemolysis at 294.3 mg/L against human red blood cells | Cytotoxicity: [Ref.25818457] The cell viability of PR-FG is 92.7%, 76%, 64%, 58%, 53%, 43%, 39%, 37% and 34% at peptide concentrations of 1.1, 2.3, 4.6, 9.2, 18.4, 36.8, 73.6, 147.1 and 294.3 µg/ml.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biomaterials. 2015 Jun 52:517-30. doi: 10.1016/j.biomaterials.2015.02.063.