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Peptide record

TPDB13547

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB13547
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 27-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FKAFKAFKAFKAFKAFKAFKAFKAFKA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C162H236N36O28
RNDCEQGHILMPSTWYV
AKF
3135.88
11.41
9
0
18
+9
0.25
0.233
33.33
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
9
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
9
K
0
M
9
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 9 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 9 M: 0 F: 9 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
27 reviewed residue count
C162H236N36O28 sequence-only estimate (linear, free termini)
3135.88 sequence-only estimate (linear, free termini)
11.41 sequence-only estimate (linear, free termini)
+9 sequence-only estimate (linear, free termini)
0.25 sequence-only estimate (linear, free termini)
0.233 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>500 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Periodic antimicrobial peptides. | PATENT US 7091185 B2 | 2006
Evidence 2 Activity

Activity

24% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
24% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Periodic antimicrobial peptides. | PATENT US 7091185 B2 | 2006