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Peptide record

TPDB13546

PTD10 (Transportan) transportan Transportan-anti-gyrA PNA/scPNA Antibacterial Cell-penetrating Peptides Hemolysis Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB13546
PTD10 (Transportan) transportan Transportan-anti-gyrA PNA/scPNA
Antibacterial Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP PD_Hemolysis
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CellPPD, and other sources, with an available 3D structural model.
Sequence
GWTLNSAGYLLGKINLKALAALAKKIL
Physicochemical Analysis
C134H226N34O33
RDCEQHMFPV
L
2841.48
10.64
4
0
16
+4
-3.08
0.633
148.52
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6990
246.00
5
Residue Composition
number
5
A
0
R
2
N
0
D
0
C
0
E
0
Q
3
G
0
H
2
I
7
L
4
K
0
M
0
F
0
P
1
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 5 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 7 K: 4 M: 0 F: 0 P: 0 S: 1 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
27
C134H226N34O33
2841.48
10.64
+4
-3.08
0.633
Free
L
Amphipathic
Linear
Free
NCC(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 7 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Vero Cells And Hk-2 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Copper/zinc superoxide dismutase (SOD1)
In vitro
CCCCCCSSCCSCCSCHHHHHHTGGGCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

S. Aureus Infected Mac-T Or Hbmec Cell Lines , Ex Vivo Calvaria (Skull Cap)

Assay & Model

Femur injury model (Wistar rats (5 to 6 wks of age))
Femur injury model (Wistar rats (5 to 6 wks of age))

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Lysostaphin and LysK
In vitro and in vivo
CCCCCCCCCCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

S. Pyogenes Strains

Assay & Model

G. mellonella Larvae
G. mellonella Larvae

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
anti-gyrA antisense PNAs and scrambled PNAs [scPNAs]
In vitro and in vivo
CTTTSCCCCHHHHHTGGGGTC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

Wheat Microspores

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Synthetic
Cys-mCherry protein
Lowest interaction with the microspore cell wall
In vitro
CCCCSCCCC
Evidence 5 Activity

Activity

38.60% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
38.60% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent Chimeric Antimicrobial Derivatives of the Medicago truncatula NCR247 Symbiotic Peptide. | Front Microbiol | 2020
Evidence 6 Activity

Activity

95.61% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
95.61% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent Chimeric Antimicrobial Derivatives of the Medicago truncatula NCR247 Symbiotic Peptide. | Front Microbiol | 2020
Evidence 7 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis
Additional Detail Fields 1 fields
CCCCCCSSCCSCCSCHHHHHHTGGGCC CCCCCCCCCCCCC CTTTSCCCCHHHHHTGGGGTC CCCCSCCCC