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Peptide record

TPDB13544

Antibacterial Antifungal Toxicity standard

27 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB13544

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 27-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.

Sequence

SKTKRRSLLKRLGDGIRGFWNGFRGRK

FASTA

>TPDB13544|Antibacterial;Antifungal;Toxicity|length=27
SKTKRRSLLKRLGDGIRGFWNGFRGRK

Formula C141H237N51O34

Absent Amino Acids ACEQHMPYV

Common Amino Acids R

Mass 3190.75

PI 12.71

Basic Residues 10

Acidic Residues 1

Hydrophobic Residues 7

Net Charge +9

Boman Index 4.82

Hydrophobicity -1.233

Aliphatic Index 57.78

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 172.37

Polar Residues 4

number

Amino Acid Distribution

A: 0 R: 6 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 1 L: 3 K: 4 M: 0 F: 2 P: 0 S: 2 T: 1 W: 1 Y: 0 V: 0

Length

Formula

C141H237N51O34

Mass

3190.75

12.71

Net Charge

Boman Index

4.82

Hydrophobicity

-1.233

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20 µM

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against E. coli ATCC25922 (MIC 20 uM), S. aureus ATCC29213 or MRSA (MIC 10 uM), S. pyogenes ATCC19615 (MIC 20 uM), S. agalactia

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µM

Target

Target Organism Staphylococcus aureus ATCC29213 or MRSA

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 20 uM), S. aureus ATCC29213 or MRSA (MIC 10 uM), S. pyogenes ATCC19615 (MIC 20 uM), S. agalactiae ATCC 12386 (MIC 20 uM), S. dysgalactiae

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20 µM

Target

Target Organism Streptococcus pyogenes ATCC19615

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 20 uM), S. aureus ATCC29213 or MRSA (MIC 10 uM), S. pyogenes ATCC19615 (MIC 20 uM), S. agalactiae ATCC 12386 (MIC 20 uM), S. dysgalactiae (MIC 20 uM), S. lutetiensis (MIC 2

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20 µM

Target

Target Organism Streptococcus agalactiae ATCC 12386

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 20 uM), S. aureus ATCC29213 or MRSA (MIC 10 uM), S. pyogenes ATCC19615 (MIC 20 uM), S. agalactiae ATCC 12386 (MIC 20 uM), S. dysgalactiae (MIC 20 uM), S. lutetiensis (MIC 20 uM), S. equi (MIC 20 uM), S. salivar

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20 µM

Target

Target Organism S. dysgalactiae

Source & Reference

Database Source dbAMP

Other

Evidence Text

RSA (MIC 10 uM), S. pyogenes ATCC19615 (MIC 20 uM), S. agalactiae ATCC 12386 (MIC 20 uM), S. dysgalactiae (MIC 20 uM), S. lutetiensis (MIC 20 uM), S. equi (MIC 20 uM), S. salivarius (MIC 10 uM), fungi C. par

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20 µM

Target

Target Organism S. lutetiensis

Source & Reference

Database Source dbAMP

Other

Evidence Text

ATCC19615 (MIC 20 uM), S. agalactiae ATCC 12386 (MIC 20 uM), S. dysgalactiae (MIC 20 uM), S. lutetiensis (MIC 20 uM), S. equi (MIC 20 uM), S. salivarius (MIC 10 uM), fungi C. parapsilosis ATCC22019 (MIC 10

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20 µM

Target

Target Organism S. equi

Source & Reference

Database Source dbAMP

Other

Evidence Text

alactiae ATCC 12386 (MIC 20 uM), S. dysgalactiae (MIC 20 uM), S. lutetiensis (MIC 20 uM), S. equi (MIC 20 uM), S. salivarius (MIC 10 uM), fungi C. parapsilosis ATCC22019 (MIC 10 uM), and C. krusei AT

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µM

Target

Target Organism S. salivarius

Source & Reference

Database Source dbAMP

Other

Evidence Text

MIC 20 uM), S. dysgalactiae (MIC 20 uM), S. lutetiensis (MIC 20 uM), S. equi (MIC 20 uM), S. salivarius (MIC 10 uM), fungi C. parapsilosis ATCC22019 (MIC 10 uM), and C. krusei ATCC6258 (MIC 20 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µM

Target

Target Organism C. parapsilosis ATCC22019

Source & Reference

Database Source dbAMP

Other

Evidence Text

20 uM), S. lutetiensis (MIC 20 uM), S. equi (MIC 20 uM), S. salivarius (MIC 10 uM), fungi C. parapsilosis ATCC22019 (MIC 10 uM), and C. krusei ATCC6258 (MIC 20 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20 µM

Target

Target Organism C. krusei ATCC6258

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 20 uM), S. salivarius (MIC 10 uM), fungi C. parapsilosis ATCC22019 (MIC 10 uM), and C. krusei ATCC6258 (MIC 20 uM).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 20 µM

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against E. coli ATCC25922 (MIC 20 uM), S. aureus ATCC29213 or MRSA (MIC 10 uM), S. pyogenes ATCC19615 (MIC 20 uM), S. agalactia

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10 µM

Target

Target Organism Staphylococcus aureus ATCC29213 or MRSA

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 20 uM), S. aureus ATCC29213 or MRSA (MIC 10 uM), S. pyogenes ATCC19615 (MIC 20 uM), S. agalactiae ATCC 12386 (MIC 20 uM), S. dysgalactiae

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 20 µM

Target

Target Organism Streptococcus pyogenes ATCC19615

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 20 µM

Target

Target Organism Streptococcus agalactiae ATCC 12386

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 20 µM

Target

Target Organism S. dysgalactiae

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 20 µM

Target

Target Organism S. lutetiensis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 20 µM

Target

Target Organism S. equi

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

alactiae ATCC 12386 (MIC 20 uM), S. dysgalactiae (MIC 20 uM), S. lutetiensis (MIC 20 uM), S. equi (MIC 20 uM), S. salivarius (MIC 10 uM), fungi C. parapsilosis ATCC22019 (MIC 10 uM), and C. krusei AT

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10 µM

Target

Target Organism S. salivarius

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

MIC 20 uM), S. dysgalactiae (MIC 20 uM), S. lutetiensis (MIC 20 uM), S. equi (MIC 20 uM), S. salivarius (MIC 10 uM), fungi C. parapsilosis ATCC22019 (MIC 10 uM), and C. krusei ATCC6258 (MIC 20 uM).

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10 µM

Target

Target Organism C. parapsilosis ATCC22019

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

20 uM), S. lutetiensis (MIC 20 uM), S. equi (MIC 20 uM), S. salivarius (MIC 10 uM), fungi C. parapsilosis ATCC22019 (MIC 10 uM), and C. krusei ATCC6258 (MIC 20 uM).

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 20 µM

Target

Target Organism C. krusei ATCC6258

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 20 uM), S. salivarius (MIC 10 uM), fungi C. parapsilosis ATCC22019 (MIC 10 uM), and C. krusei ATCC6258 (MIC 20 uM).

Evidence 21 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 50 | µM | target cell: Bovine erythrocytes

Target

Target Cell Bovine erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Marsupial and Monotreme Cathelicidins Display Antimicrobial Activity, Including Against Methicillin-Resistant Staphylococcus Aureus | Microbiology | 2017

Evidence 22 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

- | NA | target cell: Madin-Darby bovine kidney cells

Target

Target Cell Madin-Darby bovine kidney cells

Source & Reference

Database Source NA

Source Database DBAASP