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Peptide record

TPDB13541

Antibacterial Anticancer Antifungal Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB13541
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
VRRSKRGIKVPSFVKKVLKDVVSESIS
Physicochemical Analysis
C136H241N41O37
ANCQHMTWY
V
3042.66
11.58
8
2
10
+6
9.85
-0.193
107.78
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
0
A
3
R
0
N
1
D
0
C
1
E
0
Q
1
G
0
H
2
I
1
L
5
K
0
M
1
F
1
P
5
S
0
T
0
W
0
Y
6
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 2 L: 1 K: 5 M: 0 F: 1 P: 1 S: 5 T: 0 W: 0 Y: 0 V: 6
Chemical Descriptors
27
C136H241N41O37
3042.66
11.58
+6
9.85
-0.193
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

MIC assays using gram-positive strains, E. coli ATCC 25922 (MIC 1.6 uM). MOA: Can permeate and depolarize bacterial membranes.
Evidence 2 Activity

Activity

MIC
Antifungal
1.6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

Antifungipept

Other

MIC assays using gram-positive strains, E. coli ATCC 25922 (MIC 1.6 uM). MOA: Can permeate and depolarize bacterial membranes.
Evidence 3 Activity

Activity

5% Cytotoxicity
Toxicity
16 µg/mL
Cytotoxic
5% Cytotoxicity | 16 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Opossum Cathelicidins Exhibit Antimicrobial Activity Against a Broad Spectrum of Pathogens Including West Nile Virus | Front Immunol | 2020
Evidence 4 Activity

Activity

11% Cytotoxicity
Toxicity
32-64 µg/mL
Cytotoxic
11% Cytotoxicity | 32-64 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Evidence 5 Activity

Activity

0% Cytotoxicity
Toxicity
16-32 µg/mL
Cytotoxic
0% Cytotoxicity | 16-32 | µg/mL | target cell: Human Primary Epidermal Keratinocytes (HEK)

Target

Human Primary Epidermal Keratinocytes (HEK)

Source & Reference

NA
DBAASP
Opossum Cathelicidins Exhibit Antimicrobial Activity Against a Broad Spectrum of Pathogens Including West Nile Virus | Front Immunol | 2020
Evidence 6 Activity

Activity

11% Cytotoxicity
Toxicity
64 µg/mL
Cytotoxic
11% Cytotoxicity | 64 | µg/mL | target cell: Human Primary Epidermal Keratinocytes (HEK)

Target

Human Primary Epidermal Keratinocytes (HEK)

Source & Reference

NA
DBAASP
Opossum Cathelicidins Exhibit Antimicrobial Activity Against a Broad Spectrum of Pathogens Including West Nile Virus | Front Immunol | 2020
Evidence 7 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Immunol. 2020 Mar 3 11:349.