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Peptide record

TPDB13539

Antibacterial Antifungal Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB13539
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 27-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
SLWSSIKDMAAAAGRAALNAVNGIVNP
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C117H193N35O36S1
CEQHFTY
A
2698.09
10.09
2
1
15
+1
0.46
0.422
105.19
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
5500
2.04
6
Residue Composition
number
7
A
1
R
3
N
1
D
0
C
0
E
0
Q
2
G
0
H
2
I
2
L
1
K
1
M
0
F
1
P
3
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 7 R: 1 N: 3 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 2 K: 1 M: 1 F: 0 P: 1 S: 3 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
27 reviewed residue count
C117H193N35O36S1 sequence-only estimate (linear, free termini)
2698.09 sequence-only estimate (linear, free termini)
10.09 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
0.46 sequence-only estimate (linear, free termini)
0.422 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
47 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
moderately active against E. coli ATCC 25922 (MIC 47 uM).
Evidence 2 Activity

Activity

MIC
Antifungal
47 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
moderately active against E. coli ATCC 25922 (MIC 47 uM).
Evidence 3 Activity

Activity

0% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
0% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Unravelling the Skin Secretion Peptides of the Gliding Leaf Frog, Agalychnis spurrelli (Hylidae) | Biomolecules | 2019
Evidence 4 Activity

Activity

45% Hemolysis
Toxicity
512 µM
Hemolytic Cytotoxic
45% Hemolysis | 512 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Unravelling the Skin Secretion Peptides of the Gliding Leaf Frog, Agalychnis spurrelli (Hylidae) | Biomolecules | 2019