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Peptide record

TPDB13533

Antibacterial Anticancer Antifungal Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB13533
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP dbAMP 3.0 CAFPdb
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KILPGVCKKIMRPFLRRISKDILTGKK
Physicochemical Analysis
C143H256N42O32S2
ANEQHWY
K
3139.99
11.62
9
1
10
+8
6.34
-0.189
111.85
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
3
R
0
N
1
D
1
C
0
E
0
Q
2
G
0
H
4
I
3
L
6
K
1
M
1
F
2
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 1 E: 0 Q: 0 G: 2 H: 0 I: 4 L: 3 K: 6 M: 1 F: 1 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
27
C143H256N42O32S2
3139.99
11.62
+8
6.34
-0.189
Evidence Records 2 records
Evidence 1 Activity

Activity

7% Hemolysis
Toxicity
75 µM
Hemolytic Cytotoxic
7% Hemolysis | 75 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Influence of Proline Substitution on the Bioactivity of Mammalian-Derived Antimicrobial Peptide NK-2. | Probiotics Antimicrob Proteins | 2018
Evidence 2 Activity

Activity

IC50
Toxicity
32.5 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.29043494] 0% hemolysis at 10 µg/ml , 2% hemolysis at 25 µg/ml , 3% hemolysis at 50 µg/ml , 4.5% hemolysis at 75 µg/ml , 10% hemolysis at 150 µg/ml , 20% hemolysis at 300 µg/ml against human red blood cells | Cytotoxicity: [Ref.29043494] IC50 = 32.5 µM against NK-2. ##IC50 = 28.7 µM against EJ. ##IC50 = 9.6 µM against PC-3. ##IC50 = 39.6 µM against T24. ##IC50 = 48.4 µM against HL-60. ##The proliferation inhibition activity on K562 is not significant.

Target

erythrocytes

Source & Reference

NA
DRAMP
Probiotics Antimicrob Proteins. 2018 Mar 10(1):118-127. doi: 10.1007/s12602-017-9335-1.