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Peptide record

TPDB13532

Antibacterial Anticancer Antifungal Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB13532
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 27-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
FPVTWRWWKWWKGKFPVTWRWWKWWKG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C202H256N48O30
ANDCEQHILMSY
W
3836.56
12.45
7
0
14
+7
0.87
-1.070
21.48
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
55000
14.34
2
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
5
K
0
M
2
F
2
P
0
S
2
T
10
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 5 M: 0 F: 2 P: 2 S: 0 T: 2 W: 10 Y: 0 V: 2
Chemical Descriptors
27 reviewed residue count
C202H256N48O30 sequence-only estimate (linear, free termini)
3836.56 sequence-only estimate (linear, free termini)
12.45 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
0.87 sequence-only estimate (linear, free termini)
-1.070 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
<500 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | <500 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Effects of Rationally Designed Physico-Chemical Variants of the Peptide PuroA on Biocidal Activity towards Bacterial and Mammalian Cells. | Int J Mol Sci | 2020
Evidence 2 Activity

Activity

IC50
Toxicity
250 µg/mL
Cytotoxic
IC50 | 250 | µg/mL | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Effects of Rationally Designed Physico-Chemical Variants of the Peptide PuroA on Biocidal Activity towards Bacterial and Mammalian Cells. | Int J Mol Sci | 2020
Evidence 3 Activity

Activity

IC50
Toxicity
250 µg/mL
Hemolytic Cytotoxic
Hemolytic_activity: Sheep erythrocytes: No hemolysis up tp 500 µg/ml | Cytotoxicity: NIH 3T3: IC50=250 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2020 Nov 16 21(22):8624.