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Peptide record

TPDB13527

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB13527
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb PD_Hemolysis ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IDWKKVDWKKVSKKTCKVMLKACKFL
Physicochemical Analysis
C147H245N37O33S3
RNEQGHPY
K
3154.97
10.44
9
2
11
+7
4.71
-0.354
82.31
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
11125
352.62
4
Residue Composition
number
1
A
0
R
0
N
2
D
2
C
0
E
0
Q
0
G
0
H
1
I
2
L
9
K
1
M
1
F
0
P
1
S
1
T
2
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 2 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 9 M: 1 F: 1 P: 0 S: 1 T: 1 W: 2 Y: 0 V: 3
Chemical Descriptors
26
C147H245N37O33S3
3154.97
10.44
+7
4.71
-0.354
Evidence Records 13 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
15 40 %
[Ref.15639237]15% hemolytic activity at 10 µM, 40% hemolytic activity at 100 µM against human erythrocytes.

Target

human erythrocytes

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Toxicon. 2004 Feb 43(2):173-183.##Biochem Mol Biol Int. 1996 Aug 39(5):877-885.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Killing
Toxicity
0.57 µM
Cytotoxic
50% Killing | 0.57 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Delta-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities | Angew Chem Int Ed Engl | 2017
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
2.18 µM
Hemolytic Cytotoxic
50% Hemolysis | 2.18 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Delta-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities | Angew Chem Int Ed Engl | 2017
Evidence 4 Activity

Activity

50% Killing
Toxicity
0.68 µM
Cytotoxic
50% Killing | 0.68 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Delta-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities | Angew Chem Int Ed Engl | 2017
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
>12 µM
Hemolytic Cytotoxic
50% Hemolysis | >12 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Delta-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities | Angew Chem Int Ed Engl | 2017
Evidence 6 Activity

Activity

50% Killing
Toxicity
2.34 µM
Cytotoxic
50% Killing | 2.34 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Delta-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities | Angew Chem Int Ed Engl | 2017
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
>10 µM
Hemolytic Cytotoxic
50% Hemolysis | >10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Delta-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities | Angew Chem Int Ed Engl | 2017
Evidence 8 Activity

Activity

50% Killing
Toxicity
>20 µM
Cytotoxic
50% Killing | >20 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Delta-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities | Angew Chem Int Ed Engl | 2017
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
>20 µM
Hemolytic Cytotoxic
50% Hemolysis | >20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Delta-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities | Angew Chem Int Ed Engl | 2017
Evidence 10 Activity

Activity

50% Killing
Toxicity
2.4 µM
Cytotoxic
50% Killing | 2.4 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
It Takes Two: Dimerization Is Essential for the Broad-Spectrum Predatory and Defensive Activities of the Venom Peptide Mp1a from the Jack Jumper Ant Myrmecia pilosula | Biomedicines | 2020
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
>10 µM
Hemolytic Cytotoxic
50% Hemolysis | >10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
It Takes Two: Dimerization Is Essential for the Broad-Spectrum Predatory and Defensive Activities of the Venom Peptide Mp1a from the Jack Jumper Ant Myrmecia pilosula | Biomedicines | 2020
Evidence 12 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.15639237]15% hemolytic activity at 10 µM, 40% hemolytic activity at 100 µM against human erythrocytes.

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxicon. 2004 Feb 43(2):173-183.##Biochem Mol Biol Int. 1996 Aug 39(5):877-885.
Evidence 13 Hemolysis

Activity

15 40 %
% Hemolysis
[Ref.15639237]15% hemolytic activity at 10 µM, 40% hemolytic activity at 100 µM against human erythrocytes.
Hemolysis

Target

human erythrocytes

Source & Reference

PD_Hemolysis
Toxicon. 2004 Feb 43(2):173-183.##Biochem Mol Biol Int. 1996 Aug 39(5):877-885.
DRAMP4
PD_Hemolysis