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Peptide record

TPDB13508

Antibacterial Antifungal Antiparasitic Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB13508
Antibacterial Antifungal Antiparasitic Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept dbAMP 3.0 ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
NGNLLGGLLRPVLGVVKGLTGGLGKK
Physicochemical Analysis
C114H204N34O30
ADCEQHIMFSWY
G
2531.08
11.73
4
0
10
+4
1.58
0.404
138.46
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
1
R
2
N
0
D
0
C
0
E
0
Q
8
G
0
H
0
I
7
L
3
K
0
M
0
F
1
P
0
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 8 H: 0 I: 0 L: 7 K: 3 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
26
C114H204N34O30
2531.08
11.73
+4
1.58
0.404
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
62.5 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC 25922 (MIC 62.5 ug/ml) and weakly against K.pneumoniae (MIC 125 ug/ml). Thaulin-2 and Thaulin-4 showed no antiba
Evidence 2 Activity

Activity

MIC
Antibacterial
125 µg/mL

Target

K.pneumoniae

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC 25922 (MIC 62.5 ug/ml) and weakly against K.pneumoniae (MIC 125 ug/ml). Thaulin-2 and Thaulin-4 showed no antibacterial activity while Thaulin-3 showed very wea
Evidence 3 Activity

Activity

MIC
Antifungal
62.5 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC 25922 (MIC 62.5 ug/ml) and weakly against K.pneumoniae (MIC 125 ug/ml). Thaulin-2 and Thaulin-4 showed no antiba
Evidence 4 Activity

Activity

MIC
Antifungal
125 µg/mL

Target

K.pneumoniae

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against E. coli ATCC 25922 (MIC 62.5 ug/ml) and weakly against K.pneumoniae (MIC 125 ug/ml). Thaulin-2 and Thaulin-4 showed no antibacterial activity while Thaulin-3 showed very wea
Evidence 5 Activity

Activity

MIC
Antiparasitic
62.5 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against E. coli ATCC 25922 (MIC 62.5 ug/ml) and weakly against K.pneumoniae (MIC 125 ug/ml). Thaulin-2 and Thaulin-4 showed no antiba
Evidence 6 Activity

Activity

MIC
Antiparasitic
125 µg/mL

Target

K.pneumoniae

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against E. coli ATCC 25922 (MIC 62.5 ug/ml) and weakly against K.pneumoniae (MIC 125 ug/ml). Thaulin-2 and Thaulin-4 showed no antibacterial activity while Thaulin-3 showed very wea
Evidence 7 Activity

Activity

0% Hemolysis
Toxicity
125 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 125 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Thaulin-1: The first antimicrobial peptide isolated from the skin of a Patagonian frog Pleurodema thaul (Anura: Leptodactylidae: Leiuperinae) with activity against Escherichia coli. | Gene | 2017
Evidence 8 Activity

Activity

10% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Thaulin-1: The first antimicrobial peptide isolated from the skin of a Patagonian frog Pleurodema thaul (Anura: Leptodactylidae: Leiuperinae) with activity against Escherichia coli. | Gene | 2017
Evidence 9 Activity

Activity

85% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
85% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Thaulin-1: The first antimicrobial peptide isolated from the skin of a Patagonian frog Pleurodema thaul (Anura: Leptodactylidae: Leiuperinae) with activity against Escherichia coli. | Gene | 2017