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Peptide record

TPDB13503

Antibacterial Antifungal Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB13503
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb PD_Hemolysis
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FIHHIIGGLFSAGKAAHRLIRRRRR
Physicochemical Analysis
C132H220N50O27
NDCEQMPTWYV
R
2939.52
13.10
10
0
11
+7
3.76
-0.236
105.60
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
3
A
6
R
0
N
0
D
0
C
0
E
0
Q
3
G
3
H
4
I
2
L
1
K
0
M
2
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 3 I: 4 L: 2 K: 1 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
25
C132H220N50O27
2939.52
13.10
+7
3.76
-0.236
Evidence Records 4 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
10 20 35 80 95 100 %
[Ref.29040295] 10% haemolysis at 6.25 µg/ml, 20% haemolysis at 12.50 µg/ml, 35% haemolysis at 25.00 µg/ml, 80% haemolysis at 50.00 µg/ml, 95% haemolysis at 100.00 µg/ml, 100% haemolysis at 200.00 µg/ml against mouse red blood cells

Target

mouse red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
PLoS One. 2017 Oct 17 12(10):e0186442.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
25 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 25 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. | PLoS One | 2017
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic
Hemolytic_activity: [Ref.29040295] 10% haemolysis at 6.25 µg/ml, 20% haemolysis at 12.50 µg/ml, 35% haemolysis at 25.00 µg/ml, 80% haemolysis at 50.00 µg/ml, 95% haemolysis at 100.00 µg/ml, 100% haemolysis at 200.00 µg/ml against mouse red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2017 Oct 17 12(10):e0186442.
Evidence 4 Hemolysis

Activity

10 20 35 80 95 100 %
% Hemolysis
[Ref.29040295] 10% haemolysis at 6.25 µg/ml, 20% haemolysis at 12.50 µg/ml, 35% haemolysis at 25.00 µg/ml, 80% haemolysis at 50.00 µg/ml, 95% haemolysis at 100.00 µg/ml, 100% haemolysis at 200.00 µg/ml against mouse red blood cells
Hemolysis

Target

mouse red blood cells

Source & Reference

PD_Hemolysis
PLoS One. 2017 Oct 17 12(10):e0186442.
DRAMP4
PD_Hemolysis