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Peptide record

TPDB13499

Antibacterial Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB13499
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 25-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RKFLRRRGEVAHFSQKSLGLYCWWW
Physicochemical Analysis
C151H221N45O32S1
NDIMPT
R
3210.76
11.34
7
1
11
+5
-1.71
-0.676
62.40
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
17990
560.30
5
Residue Composition
number
1
A
4
R
0
N
0
D
1
C
1
E
1
Q
2
G
1
H
0
I
3
L
2
K
0
M
2
F
0
P
2
S
0
T
3
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 1 E: 1 Q: 1 G: 2 H: 1 I: 0 L: 3 K: 2 M: 0 F: 2 P: 0 S: 2 T: 0 W: 3 Y: 1 V: 1
Chemical Descriptors
25
C151H221N45O32S1
3210.76
11.34
+5
-1.71
-0.676
Evidence Records 6 records
Evidence 1 Activity

Activity

<=5% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
<=5% Hemolysis | 512 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 2 Activity

Activity

0% Killing
Toxicity
<256 µg/mL
Cytotoxic
0% Killing | <256 | µg/mL | target cell: Murine dendritic cells JAWS II

Target

Murine dendritic cells JAWS II

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 3 Activity

Activity

7% Killing
Toxicity
512 µg/mL
Cytotoxic
7% Killing | 512 | µg/mL | target cell: Murine dendritic cells JAWS II

Target

Murine dendritic cells JAWS II

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 4 Activity

Activity

0% Killing
Toxicity
<128 µg/mL
Cytotoxic
0% Killing | <128 | µg/mL | target cell: Chinese hamster ovary cells CHO-K1

Target

Chinese hamster ovary cells CHO-K1

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 5 Activity

Activity

7% Killing
Toxicity
256 µg/mL
Cytotoxic
7% Killing | 256 | µg/mL | target cell: Chinese hamster ovary cells CHO-K1

Target

Chinese hamster ovary cells CHO-K1

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 6 Activity

Activity

20% Killing
Toxicity
512 µg/mL
Cytotoxic
20% Killing | 512 | µg/mL | target cell: Chinese hamster ovary cells CHO-K1

Target

Chinese hamster ovary cells CHO-K1

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018