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Peptide record

TPDB13496

Antibacterial Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB13496
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 25-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RFRPPIRRPPIRPPFYPPFRPPIRP
Physicochemical Analysis
C151H232N46O27
ANDCEQGHLKMSTWV
P
3123.80
12.80
7
0
7
+7
5.36
-1.140
46.80
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
47.70
1
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
3
I
0
L
0
K
0
M
3
F
11
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 0 K: 0 M: 0 F: 3 P: 11 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
25
C151H232N46O27
3123.80
12.80
+7
5.36
-1.140
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1 µM

Target

Escherichia coli BW25113 or ATCC 25922

Source & Reference

NA

Other

active against Gram- E. coli BW25113 or ATCC 25922 (MIC 1 uM), A. baumannii ATCC 19606 (MIC 1 uM), S. enterica ATCC 14028 (MIC 8 uM), K. pneumoniae ATC
Evidence 2 Activity

Activity

MIC
Antibacterial
1 µM

Target

A. baumannii ATCC 19606

Source & Reference

NA

Other

active against Gram- E. coli BW25113 or ATCC 25922 (MIC 1 uM), A. baumannii ATCC 19606 (MIC 1 uM), S. enterica ATCC 14028 (MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 32 uM), P-aeruginosa A
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µM

Target

S. enterica ATCC 14028

Source & Reference

NA

Other

ainst Gram- E. coli BW25113 or ATCC 25922 (MIC 1 uM), A. baumannii ATCC 19606 (MIC 1 uM), S. enterica ATCC 14028 (MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 32 uM), P-aeruginosa ATCC 27853 (MIC > 64 uM), and S-aure
Evidence 4 Activity

Activity

MIC
Antibacterial
32 µM

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

NA

Other

25922 (MIC 1 uM), A. baumannii ATCC 19606 (MIC 1 uM), S. enterica ATCC 14028 (MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 32 uM), P-aeruginosa ATCC 27853 (MIC > 64 uM), and S-aureus ATCC 25923 (MIC > 64 uM). bactericid
Evidence 5 Activity

Activity

30% Killing
Toxicity
64 µM
Cytotoxic
30% Killing | 64 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Search for Shorter Portions of the Proline-Rich Antimicrobial Peptide Fragment Bac5(1-25) That Retain Antimicrobial Activity by Blocking Protein Synthesis. | ChemMedChem | 2019
Evidence 6 Activity

Activity

0% Killing
Toxicity
<32 µM
Cytotoxic
0% Killing | <32 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Fragments of the Nonlytic Proline-Rich Antimicrobial Peptide Bac5 Kill Escherichia coli Cells by Inhibiting Protein Synthesis. | Antimicrob Agents Chemother | 2018