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Peptide record

TPDB13483

Antibacterial Antifungal Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB13483
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 25-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GFSSLFKAGAKYLAKQVGKAGAQQL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C118H190N32O32
RNDCEHIMPTW
A
2569.00
10.64
4
0
12
+4
0.33
-0.016
78.40
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
0.58
6
Residue Composition
number
5
A
0
R
0
N
0
D
0
C
0
E
3
Q
4
G
0
H
0
I
3
L
4
K
0
M
2
F
0
P
2
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 5 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 3 G: 4 H: 0 I: 0 L: 3 K: 4 M: 0 F: 2 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
25 reviewed residue count
C118H190N32O32 sequence-only estimate (linear, free termini)
2569.00 sequence-only estimate (linear, free termini)
10.64 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
0.33 sequence-only estimate (linear, free termini)
-0.016 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

8% Killing
Toxicity
100 µM
Cytotoxic
8% Killing | 100 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Brevinin-2GHk From Sylvirana guentheri and the Design of Truncated Analogs Exhibiting the Enhancement of Antimicrobial Activity | Antibiotics (Basel) | 2020
Evidence 2 Activity

Activity

<5% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
<5% Hemolysis | 128 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Brevinin-2GHk From Sylvirana guentheri and the Design of Truncated Analogs Exhibiting the Enhancement of Antimicrobial Activity | Antibiotics (Basel) | 2020