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Peptide record

TPDB13472

Antibacterial Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB13472
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
AGTNRIAKELRRYIRKVGRIARKWW
Physicochemical Analysis
C140H233N49O31
DCQHMFPS
R
3098.70
12.41
9
1
11
+8
3.86
-0.936
86.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
12490
403.07
3
Residue Composition
number
3
A
6
R
1
N
0
D
0
C
1
E
0
Q
2
G
0
H
3
I
1
L
3
K
0
M
0
F
0
P
0
S
1
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 3 R: 6 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 3 L: 1 K: 3 M: 0 F: 0 P: 0 S: 0 T: 1 W: 2 Y: 1 V: 1
Chemical Descriptors
25
C140H233N49O31
3098.70
12.41
+8
3.86
-0.936
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
Antibacterial
1.64 µM

Target

L. donovani

Source & Reference

NA

Other

exhibits leishmanicidal activity against L. donovani (IC50 1.64 uM).
Evidence 2 Activity

Activity

18.8% Hemolysis
Toxicity
<0.25 µM
Hemolytic Cytotoxic
18.8% Hemolysis | <0.25 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Synthetic Peptide Libraries Designed From a Minimal Alpha-Helical Domain of AS-48-Bacteriocin Homologs Exhibit Potent Antibacterial Activity. | Front Microbiol | 2020
Evidence 3 Activity

Activity

23% Cytotoxicity
Toxicity
32 µM
Cytotoxic
23% Cytotoxicity | 32 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Synthetic Peptide Libraries Designed From a Minimal Alpha-Helical Domain of AS-48-Bacteriocin Homologs Exhibit Potent Antibacterial Activity. | Front Microbiol | 2020
Evidence 4 Activity

Activity

40% Cytotoxicity
Toxicity
64 µM
Cytotoxic
40% Cytotoxicity | 64 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Synthetic Peptide Libraries Designed From a Minimal Alpha-Helical Domain of AS-48-Bacteriocin Homologs Exhibit Potent Antibacterial Activity. | Front Microbiol | 2020
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis