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Peptide record

TPDB13471

Antibacterial Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB13471
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
AWTEKIFNRLKKTINEGKKIAKRAW
Physicochemical Analysis
C140H229N41O34
DCQHMPSYV
K
3030.61
11.16
8
2
10
+6
5.90
-0.980
74.40
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
11000
362.96
4
Residue Composition
number
3
A
2
R
2
N
0
D
0
C
2
E
0
Q
1
G
0
H
3
I
1
L
6
K
0
M
1
F
0
P
0
S
2
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 2 N: 2 D: 0 C: 0 E: 2 Q: 0 G: 1 H: 0 I: 3 L: 1 K: 6 M: 0 F: 1 P: 0 S: 0 T: 2 W: 2 Y: 0 V: 0
Chemical Descriptors
25
C140H229N41O34
3030.61
11.16
+6
5.90
-0.980
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
Antibacterial
8.35 µM

Target

L. donovani

Source & Reference

NA

Other

exhibits leishmanicidal activity against L. donovani (IC50 8.35 uM).
Evidence 2 Activity

Activity

17.5% Hemolysis
Toxicity
>32 µM
Hemolytic Cytotoxic
17.5% Hemolysis | >32 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Synthetic Peptide Libraries Designed From a Minimal Alpha-Helical Domain of AS-48-Bacteriocin Homologs Exhibit Potent Antibacterial Activity. | Front Microbiol | 2020
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis