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Peptide record

TPDB13460

Antibacterial Anticancer Antifungal Toxicity standard

25 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB13460

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb dbAMP ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.

Sequence

GLWSKIKDAAKTAGKAALGFVNEMV

FASTA

>TPDB13460|Antibacterial;Anticancer;Antifungal;Toxicity|length=25
GLWSKIKDAAKTAGKAALGFVNEMV

Formula C118H193N31O33S1

Absent Amino Acids RCQHPY

Common Amino Acids A

Mass 2606.08

PI 10.16

Basic Residues 4

Acidic Residues 2

Hydrophobic Residues 13

Net Charge +2

Boman Index 2.58

Hydrophobicity 0.180

Aliphatic Index 90.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 211.05

Polar Residues 3

number

Amino Acid Distribution

A: 5 R: 0 N: 1 D: 1 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 1 L: 2 K: 4 M: 1 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 2

Length

Formula

C118H193N31O33S1

Mass

2606.08

10.16

Net Charge

Boman Index

2.58

Hydrophobicity

0.180

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µM

Target

Target Organism Staphylococcus aureus NCTC 10788

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Broad spectrum, active against S. aureus NCTC 10788 (MIC 16 uM), MRSA NCTC 12493 (MIC 32 uM), E. faecalis NCTC 12697 (MIC 16 uM), Gram- E. coli NCTC 1041

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µM

Target

Target Organism Enterococcus faecalis NCTC 12697

Source & Reference

Database Source dbAMP

Other

Evidence Text

d spectrum, active against S. aureus NCTC 10788 (MIC 16 uM), MRSA NCTC 12493 (MIC 32 uM), E. faecalis NCTC 12697 (MIC 16 uM), Gram- E. coli NCTC 10418 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), K. pneumoniae

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Escherichia coli NCTC 10418

Source & Reference

Database Source dbAMP

Other

Evidence Text

10788 (MIC 16 uM), MRSA NCTC 12493 (MIC 32 uM), E. faecalis NCTC 12697 (MIC 16 uM), Gram- E. coli NCTC 10418 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), and C. albica

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP

Other

Evidence Text

493 (MIC 32 uM), E. faecalis NCTC 12697 (MIC 16 uM), Gram- E. coli NCTC 10418 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), and C. albicans NCYC 1467 (MIC 64 uM). MBC is usual

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Klebsiella pneumoniae ATCC 43816

Source & Reference

Database Source dbAMP

Other

Evidence Text

7 (MIC 16 uM), Gram- E. coli NCTC 10418 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), and C. albicans NCYC 1467 (MIC 64 uM). MBC is usually 2 fold higher than MIC.

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64 µM

Target

Target Organism Candida albicans NCYC 1467

Source & Reference

Database Source dbAMP

Other

Evidence Text

MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), and C. albicans NCYC 1467 (MIC 64 uM). MBC is usually 2 fold higher than MIC.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µM

Target

Target Organism Staphylococcus aureus NCTC 10788

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Broad spectrum, active against S. aureus NCTC 10788 (MIC 16 uM), MRSA NCTC 12493 (MIC 32 uM), E. faecalis NCTC 12697 (MIC 16 uM), Gram- E. coli NCTC 1041

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µM

Target

Target Organism Enterococcus faecalis NCTC 12697

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Escherichia coli NCTC 10418

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Klebsiella pneumoniae ATCC 43816

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 64 µM

Target

Target Organism Candida albicans NCYC 1467

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), and C. albicans NCYC 1467 (MIC 64 uM). MBC is usually 2 fold higher than MIC.

Evidence 13 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 51.04 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 51.04 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Target Cell Human microvascular endothelial cells HMEC-1

Source & Reference

Database Source NA

Source Database DBAASP

Reference

A Novel Dermaseptin Isolated from the Skin Secretion of Phyllomedusa tarsius and Its Cationicity-Enhanced Analogue Exhibiting Effective Antimicrobial and Anti-Proliferative Activities. | Biomolecules | 2019

Evidence 14 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 210 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 210 | µM | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference