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Peptide record

TPDB13457

Antibacterial Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB13457
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 25-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
AGKEKIRKKLKNEIKKKWRKAVIAW
Physicochemical Analysis
C142H245N43O31
DCQHMFPSTY
K
3050.78
11.34
11
2
10
+9
9.37
-1.196
86.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
11000
360.56
1
Residue Composition
number
3
A
2
R
1
N
0
D
0
C
2
E
0
Q
1
G
0
H
3
I
1
L
9
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 2 N: 1 D: 0 C: 0 E: 2 Q: 0 G: 1 H: 0 I: 3 L: 1 K: 9 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
25
C142H245N43O31
3050.78
11.34
+9
9.37
-1.196
Evidence Records 2 records
Evidence 1 Activity

Activity

18% Cytotoxicity
Toxicity
64 µg/mL
Cytotoxic
18% Cytotoxicity | 64 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy. | ACS Pharmacol Transl Sci | 2020
Evidence 2 Activity

Activity

<5% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 128 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy. | ACS Pharmacol Transl Sci | 2020