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Peptide record

TPDB13451

Antibacterial Anticancer Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB13451
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RFRLPFRRPPIRIPPPFYPPFRRFL
Physicochemical Analysis
C160H240N46O27
ANDCEQGHKMSTWV
P
3239.96
12.80
7
0
10
+7
0.94
-0.600
62.40
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
45.99
1
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
2
L
0
K
0
M
5
F
8
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 2 K: 0 M: 0 F: 5 P: 8 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
25
C160H240N46O27
3239.96
12.80
+7
0.94
-0.600
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
34.7±7.3 µM
Cytotoxic
50% Cytotoxicity | 34.7±7.3 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs. | Front Cell Infect Microbiol | 2020
Evidence 2 Activity

Activity

<5% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
<5% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs. | Front Cell Infect Microbiol | 2020
Evidence 3 Activity

Activity

IC50
Toxicity
34.7
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: <5% Hemolysis=64 µM | Cytotoxicity: Human PBMC: IC50=34.7 ± 7.3 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Cell Infect Microbiol. 2020 Oct 19 10:552905.