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Peptide record

TPDB13444

Antibacterial Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB13444
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 25-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
AWTQRIKAYLRREIRKRGRKAVIAW
Physicochemical Analysis
C142H237N49O31
NDCHMFPS
R
3126.75
12.41
9
1
12
+8
3.84
-0.848
90.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
12490
399.46
3
Residue Composition
number
4
A
6
R
0
N
0
D
0
C
1
E
1
Q
1
G
0
H
3
I
1
L
3
K
0
M
0
F
0
P
0
S
1
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 4 R: 6 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 1 H: 0 I: 3 L: 1 K: 3 M: 0 F: 0 P: 0 S: 0 T: 1 W: 2 Y: 1 V: 1
Chemical Descriptors
25
C142H237N49O31
3126.75
12.41
+8
3.84
-0.848
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
Antibacterial
12.98 µM

Target

L. donovani

Source & Reference

NA

Other

exhibits leishmanicidal activity against L. donovani (IC50 12.98 uM).
Evidence 2 Activity

Activity

7% Cytotoxicity
Toxicity
32 µM
Cytotoxic
7% Cytotoxicity | 32 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Synthetic Peptide Libraries Designed From a Minimal Alpha-Helical Domain of AS-48-Bacteriocin Homologs Exhibit Potent Antibacterial Activity. | Front Microbiol | 2020
Evidence 3 Activity

Activity

40% Cytotoxicity
Toxicity
64 µM
Cytotoxic
40% Cytotoxicity | 64 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Synthetic Peptide Libraries Designed From a Minimal Alpha-Helical Domain of AS-48-Bacteriocin Homologs Exhibit Potent Antibacterial Activity. | Front Microbiol | 2020