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Peptide record

TPDB13433

Antibacterial Anticancer Antifungal Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB13433
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 Antifungipept CAFPdb dbAMP
standard
No
A 25-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
GLWSKIKKAAKTAGKAALGFVNKMV
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C121H205N33O29S1
RDCEQHPY
K
2618.22
11.21
6
0
13
+6
0.14
0.148
90.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
2.10
3
Residue Composition
number
5
A
0
R
1
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
2
L
6
K
1
M
1
F
0
P
1
S
1
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 5 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 2 K: 6 M: 1 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 2
Chemical Descriptors
25 reviewed residue count
C121H205N33O29S1 sequence-only estimate (linear, free termini)
2618.22 sequence-only estimate (linear, free termini)
11.21 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
0.14 sequence-only estimate (linear, free termini)
0.148 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Toxicity
48.80 µM
Cytotoxic
IC50 | 48.80 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
A Novel Dermaseptin Isolated from the Skin Secretion of Phyllomedusa tarsius and Its Cationicity-Enhanced Analogue Exhibiting Effective Antimicrobial and Anti-Proliferative Activities. | Biomolecules | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
107 µM
Hemolytic Cytotoxic
50% Hemolysis | 107 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
A Novel Dermaseptin Isolated from the Skin Secretion of Phyllomedusa tarsius and Its Cationicity-Enhanced Analogue Exhibiting Effective Antimicrobial and Anti-Proliferative Activities. | Biomolecules | 2019