Back to search

Peptide record

TPDB13414

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB13414
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept ToxinPred 3.0
standard
No
A 24-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LLKELWTKMKGAGKAVLGKIKGLL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C122H215N31O28S1
RNDCQHFPSY
LK
2596.30
10.82
6
1
12
+5
-0.33
0.287
134.17
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
2.12
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
1
E
0
Q
4
G
0
H
1
I
6
L
6
K
1
M
0
F
0
P
0
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 4 H: 0 I: 1 L: 6 K: 6 M: 1 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
24 reviewed residue count
C122H215N31O28S1 sequence-only estimate (linear, free termini)
2596.30 sequence-only estimate (linear, free termini)
10.82 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
-0.33 sequence-only estimate (linear, free termini)
0.287 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
15 µM
Hemolytic Cytotoxic
0% Hemolysis | 15 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Investigation of the structure-activity relationship in ponericin L1 from Neoponera goeldii. | Pept Sci (Hoboken) | 2020
Evidence 2 Activity

Activity

0.2% Hemolysis
Toxicity
2 µg/mL
Hemolytic Cytotoxic
0.2% Hemolysis | 2 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial potential of a ponericin-like peptide isolated from Bombyx mori L. hemolymph in response to Pseudomonas aeruginosa infection. | Sci Rep | 2022
Evidence 3 Activity

Activity

0% Cytotoxicity
Toxicity
2 µg/mL
Cytotoxic
0% Cytotoxicity | 2 | µg/mL | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Antimicrobial potential of a ponericin-like peptide isolated from Bombyx mori L. hemolymph in response to Pseudomonas aeruginosa infection. | Sci Rep | 2022