TPDB

3D PDB MODEL

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TPDB ID TPDB13403

Peptide_Name

Brevinin-1BLa

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLPIIAGVAAKVLPKIFCAISKKC

FASTA

>TPDB13403|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=24
FLPIIAGVAAKVLPKIFCAISKKC

Formula C121H204N28O26S2

Absent Amino Acids RNDEQHMTWY

Common Amino Acids AIK

Mass 2531.24

PI 10.17

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 14

Net Charge +4

Boman Index -0.64

Hydrophobicity 1.325

Aliphatic Index 138.33

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 125

Absorbance 280nm 4.94

Polar Residues 3

number

4

A

0

R

0

N

0

D

2

C

0

E

0

Q

1

G

0

H

4

I

2

L

4

K

0

M

2

F

2

P

1

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 4 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 4 L: 2 K: 4 M: 0 F: 2 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 2

Length

24

Formula

C121H204N28O26S2

Mass

2531.24

PI

10.17

Net Charge

+4

Boman Index

-0.64

Hydrophobicity

1.325

C_terminal_Modification

Free

Chirality

L

Linear_or_Cyclic

Not Available

N_terminal_Modification

Free

Nature

Antibacterial

Origin

North America, leopard frog, Lithobates blairi

Evidence 1 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Not Available

Cell Line Not Available

Tissue Affected Not Available

Assay & Model

Assay Not Available

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2009

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Hemolysis

Source & Reference

source APD_complete APD_hemolytic

Database Source APD_complete APD_hemolytic

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.