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Peptide record

TPDB13394

Antibacterial Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB13394
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 24-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LKKWWKTSKGLLGGLLGKVTSVIK
Physicochemical Analysis
C126H214N32O29
ARNDCEQHMFPY
K
2641.28
11.21
6
0
10
+6
-0.15
0.087
121.67
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
11000
416.46
4
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
1
I
5
L
6
K
0
M
0
F
0
P
2
S
2
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 1 L: 5 K: 6 M: 0 F: 0 P: 0 S: 2 T: 2 W: 2 Y: 0 V: 2
Chemical Descriptors
24
C126H214N32O29
2641.28
11.21
+6
-0.15
0.087
Evidence Records 3 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
<64 µM
Hemolytic Cytotoxic
<5% Hemolysis | <64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial Properties and Efficacy of a Novel SPLUNC1-Derived Antimicrobial Peptide, ?4-Short, in a Murine Model of Respiratory Infection. | MBio | 2019
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Antibacterial Properties and Efficacy of a Novel SPLUNC1-Derived Antimicrobial Peptide, ?4-Short, in a Murine Model of Respiratory Infection. | MBio | 2019
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
1 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.30967458] 1% hemolysis at 17 µM, 2% hemolysis at 30 µM, 3% hemolysis at 63 µM against human red blood cells | Cytotoxicity: [Ref.30967458] The white blood cell toxicity of α4-short is ~0%, ~0%, ~0%, ~0%, ~0%, 1.8% and 3.1% at peptide concentrations of 1, 2, 4, 8, 16, 32 and 64 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
mBio. 2019 Mar-Apr 10(2): e00226-19. Published online 2019 Apr 9. doi: 10.1128/mBio.00226-19