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Peptide record

TPDB13392

Antibacterial Antifungal Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB13392
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 23-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KNVNSIVKIQAFFRARKAQDDYR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C123H199N39O34
CEGHLMPTW
ARK
2768.17
10.87
6
2
10
+4
3.37
-0.865
72.17
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
0.54
6
Residue Composition
number
3
A
3
R
2
N
2
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
3
K
0
M
2
F
0
P
1
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 3 R: 3 N: 2 D: 2 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 3 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
23 reviewed residue count
C123H199N39O34 sequence-only estimate (linear, free termini)
2768.17 sequence-only estimate (linear, free termini)
10.87 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
3.37 sequence-only estimate (linear, free termini)
-0.865 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
12 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 12 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
IQ-motif peptides as novel anti-microbial agents. | Biochimie | 2013
Evidence 2 Activity

Activity

2% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
IQ-motif peptides as novel anti-microbial agents. | Biochimie | 2013