Back to search

Peptide record

TPDB13390

Antibacterial Antifungal Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB13390
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia CAFPdb dbAMP ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GVTFNALKGVAKTVAAQLLKTAR
Physicochemical Analysis
C106H185N31O29
DCEHIMPSWY
A
2357.83
11.73
4
0
12
+4
1.77
0.422
110.43
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
5
A
1
R
1
N
0
D
0
C
0
E
1
Q
2
G
0
H
0
I
3
L
3
K
0
M
1
F
0
P
0
S
3
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 5 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 3 K: 3 M: 0 F: 1 P: 0 S: 0 T: 3 W: 0 Y: 0 V: 3
Chemical Descriptors
23
C106H185N31O29
2357.83
11.73
+4
1.77
0.422
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
16 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ bacteria S. aureus (MIC 16 uM), S.mutans (MIC >100 uM), Gram- E. coli (MIC 64 uM), P.aeruginosa, and fungi C.albicans (M
Evidence 2 Activity

Activity

MIC
Antibacterial
>100 µM

Target

S.mutans

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ bacteria S. aureus (MIC 16 uM), S.mutans (MIC >100 uM), Gram- E. coli (MIC 64 uM), P.aeruginosa, and fungi C.albicans (MIC >100 uM). It also inh
Evidence 3 Activity

Activity

MIC
Antibacterial
64 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ bacteria S. aureus (MIC 16 uM), S.mutans (MIC >100 uM), Gram- E. coli (MIC 64 uM), P.aeruginosa, and fungi C.albicans (MIC >100 uM). It also inhibited 70% biofilm formatio
Evidence 4 Activity

Activity

MIC
Antibacterial
>100 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP

Other

s (MIC 16 uM), S.mutans (MIC >100 uM), Gram- E. coli (MIC 64 uM), P.aeruginosa, and fungi C.albicans (MIC >100 uM). It also inhibited 70% biofilm formation of S. aureus at 0.5 MIC and completely inhibited
Evidence 5 Activity

Activity

MIC
Antifungal
16 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.
Active against Gram+ bacteria S. aureus (MIC 16 uM), S.mutans (MIC >100 uM), Gram- E. coli (MIC 64 uM), P.aeruginosa, and fungi C.albicans (M
Evidence 6 Activity

Activity

MIC
Antifungal
>100 µM

Target

S.mutans

Source & Reference

dbAMP DRAMP CAFPdb

Other

Active against Gram+ bacteria S. aureus (MIC 16 uM), S.mutans (MIC >100 uM), Gram- E. coli (MIC 64 uM), P.aeruginosa, and fungi C.albicans (MIC >100 uM). It also inh
Evidence 7 Activity

Activity

MIC
Antifungal
64 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb

Other

Active against Gram+ bacteria S. aureus (MIC 16 uM), S.mutans (MIC >100 uM), Gram- E. coli (MIC 64 uM), P.aeruginosa, and fungi C.albicans (MIC >100 uM). It also inhibited 70% biofilm formatio
Evidence 8 Activity

Activity

MIC
Antifungal
>100 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP CAFPdb

Other

s (MIC 16 uM), S.mutans (MIC >100 uM), Gram- E. coli (MIC 64 uM), P.aeruginosa, and fungi C.albicans (MIC >100 uM). It also inhibited 70% biofilm formation of S. aureus at 0.5 MIC and completely inhibited
Evidence 9 Activity

Activity

0.13±0.006% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
0.13±0.006% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Brevinin-GR23 from frog Hylarana guentheri with antimicrobial and antibiofilm activities against Staphylococcus aureus. | Biosci Biotechnol Biochem | 2019
Evidence 10 Activity

Activity

1.6±0.011% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
1.6±0.011% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Brevinin-GR23 from frog Hylarana guentheri with antimicrobial and antibiofilm activities against Staphylococcus aureus. | Biosci Biotechnol Biochem | 2019
Evidence 11 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.31549575]B-GR23 induced a hemolysis of 0.13%, 0.23%, 0.38%, 0.75%, 0.83% and 1.60% on human blood red cells at the concentrations of 25, 50, 75, 100, 150 and 200 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biosci Biotechnol Biochem. 2020 Jan 84(1):143-153. doi: 10.1080/09168451.2019.1670045. Epub 2019 Sep 24.