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Peptide record

TPDB13383

Antibacterial Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB13383
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 23-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GLLRASSKWGRKYYVDLAGCAKA
Physicochemical Analysis
C113H181N33O30S1
NEQHIMFPT
A
2513.94
10.23
5
1
11
+4
-0.15
-0.226
80.87
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8480
337.32
5
Residue Composition
number
4
A
2
R
0
N
1
D
1
C
0
E
0
Q
3
G
0
H
0
I
3
L
3
K
0
M
0
F
0
P
2
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 4 R: 2 N: 0 D: 1 C: 1 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 3 K: 3 M: 0 F: 0 P: 0 S: 2 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
23
C113H181N33O30S1
2513.94
10.23
+4
-0.15
-0.226
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
670 µM
Hemolytic Cytotoxic
50% Hemolysis | 670 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Selection and redesign for high selectivity of membrane-active antimicrobial peptides from a dedicated sequence/function database. | Biochim Biophys Acta | 2019
Evidence 2 Activity

Activity

IC50
Toxicity
315.4 µg/mL
Cytotoxic
IC50 | 315.4 | µg/mL | target cell: Human osteoblast-like cells

Target

Human osteoblast-like cells

Source & Reference

NA
DBAASP
Antibacterial Activity on Orthopedic Clinical Isolates and Cytotoxicity of the Antimicrobial Peptide Dadapin-1. | Int J Mol Sci | 2023