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Peptide record

TPDB13366

Antibacterial Anticancer Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB13366
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RFRRLRWKTRWRLKKIWWPFLRR
Physicochemical Analysis
C161H250N54O25
ANDCEQGHMSYV
R
3342.10
13.25
11
0
10
+11
-1.61
-1.396
67.83
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
658.27
1
Residue Composition
number
0
A
8
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
3
L
3
K
0
M
2
F
1
P
0
S
1
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 3 M: 0 F: 2 P: 1 S: 0 T: 1 W: 4 Y: 0 V: 0
Chemical Descriptors
23
C161H250N54O25
3342.10
13.25
+11
-1.61
-1.396
Evidence Records 2 records
Evidence 1 Activity

Activity

22% Hemolysis
Toxicity
294.3 µg/mL
Hemolytic Cytotoxic
22% Hemolysis | 294.3 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of cell selectivity, physiological stability and endotoxin neutralization capabilities of ?-helix-based peptide amphiphiles. | Biomaterials | 2015
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.25818457] 0% hemolysis at 9.2 mg/L , 1% hemolysis at 18.4 mg/L , 4% hemolysis at 36.8mg/L , 10% hemolysis at 73.6 mg/L , 17% hemolysis at 147.1 mg/L , 22% hemolysis at 294.3 mg/L against human red blood cells | Cytotoxicity: [Ref.25818457] The cell viability of PR-TR is 94%, 89%, 83%, 77%, 74%, 71%, 68%, 66% and 60% at peptide concentrations of 1.1, 2.3, 4.6, 9.2, 18.4, 36.8, 73.6, 147.1 and 294.3 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Biomaterials. 2015 Jun 52:517-30. doi: 10.1016/j.biomaterials.2015.02.063.