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Peptide record

TPDB13358

Antibacterial Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB13358
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 23-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
KRFWPLVPVAINTVALYKAIRRK
Physicochemical Analysis
C131H215N37O27
DCEQGHMS
ARKV
2740.38
12.15
6
0
13
+6
0.90
0.113
118.70
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
6990
255.07
3
Residue Composition
number
3
A
3
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
2
L
3
K
0
M
1
F
2
P
0
S
1
T
1
W
1
Y
3
V
Amino Acid Distribution
A: 3 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 2 K: 3 M: 0 F: 1 P: 2 S: 0 T: 1 W: 1 Y: 1 V: 3
Chemical Descriptors
23
C131H215N37O27
2740.38
12.15
+6
0.90
0.113
Evidence Records 2 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
<5% Hemolysis | 256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The Central Hinge Link Truncation of the Antimicrobial Peptide Fowlicidin-3 Enhances Its Cell Selectivity without Antibacterial Activity Loss. | Antimicrob Agents Chemother | 2016
Evidence 2 Activity

Activity

<40% Killing
Toxicity
256 µM
Cytotoxic
<40% Killing | 256 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
The Central Hinge Link Truncation of the Antimicrobial Peptide Fowlicidin-3 Enhances Its Cell Selectivity without Antibacterial Activity Loss. | Antimicrob Agents Chemother | 2016