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Peptide record

TPDB13356

Antibacterial Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB13356
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 23-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GIKKWLHSAKKFGKKFVKKIMNS
Physicochemical Analysis
C128H211N35O27S1
RDCEQPTY
K
2704.36
11.36
9
0
9
+8
3.96
-0.648
67.83
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
203.38
3
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
1
H
2
I
1
L
8
K
1
M
2
F
0
P
2
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 2 L: 1 K: 8 M: 1 F: 2 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
23
C128H211N35O27S1
2704.36
11.36
+8
3.96
-0.648
Evidence Records 2 records
Evidence 1 Activity

Activity

98% Killing
Toxicity
100 µM
Cytotoxic
98% Killing | 100 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Improvement of Therapeutic Index by the Combination of Enhanced Peptide Cationicity and Proline Introduction. | ACS Infect Dis | 2020
Evidence 2 Activity

Activity

90% Killing
Toxicity
100 µM
Cytotoxic
90% Killing | 100 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Improvement of Therapeutic Index by the Combination of Enhanced Peptide Cationicity and Proline Introduction. | ACS Infect Dis | 2020