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Peptide record

TPDB13351

Antibacterial Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB13351
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 23-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GGGKALHSFKKFIKAFVGEIMNS
Physicochemical Analysis
C114H180N30O29S1
RDCQPTWY
GK
2466.93
10.55
5
1
10
+3
2.59
0.083
72.17
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
1
E
0
Q
4
G
1
H
2
I
1
L
4
K
1
M
3
F
0
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 4 H: 1 I: 2 L: 1 K: 4 M: 1 F: 3 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
23
C114H180N30O29S1
2466.93
10.55
+3
2.59
0.083
Evidence Records 3 records
Evidence 1 Activity

Activity

16% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
16% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Inducing toxicity by introducing a leucine-zipper-like motif in frog antimicrobial peptide, magainin 2. | Biochem J | 2011
Evidence 2 Activity

Activity

100% Killing
Toxicity
80 µM
Cytotoxic
100% Killing | 80 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Inducing toxicity by introducing a leucine-zipper-like motif in frog antimicrobial peptide, magainin 2. | Biochem J | 2011
Evidence 3 Activity

Activity

55% Killing
Toxicity
100 µM
Cytotoxic
55% Killing | 100 | µM | target cell: Chinese hamster ovary cells CHO-K1

Target

Chinese hamster ovary cells CHO-K1

Source & Reference

NA
DBAASP
Inducing toxicity by introducing a leucine-zipper-like motif in frog antimicrobial peptide, magainin 2. | Biochem J | 2011