TPDB

3D PDB MODEL

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TPDB ID TPDB13344

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP pep-lab Peptipedia Antifungipept APD_complete APD_hemolytic Hemolytic2 ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

VIPFVASVAAEMQHVYCAASRKC

FASTA

>TPDB13344|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=23
VIPFVASVAAEMQHVYCAASRKC

Formula C109H174N30O30S3

Absent Amino Acids NDGLTW

Common Amino Acids A

Mass 2480.94

PI 8.28

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 13

Net Charge +1

Boman Index 2.41

Hydrophobicity 0.735

Aliphatic Index 89.13

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1615

Absorbance 280nm 65.10

Polar Residues 6

number

5

A

1

R

0

N

0

D

2

C

1

E

1

Q

0

G

1

H

1

I

0

L

1

K

1

M

1

F

1

P

2

S

0

T

0

W

1

Y

4

V

Amino Acid Distribution

A: 5 R: 1 N: 0 D: 0 C: 2 E: 1 Q: 1 G: 0 H: 1 I: 1 L: 0 K: 1 M: 1 F: 1 P: 1 S: 2 T: 0 W: 0 Y: 1 V: 4

Length

23

Formula

C109H174N30O30S3

Mass

2480.94

PI

8.28

Net Charge

+1

Boman Index

2.41

Hydrophobicity

0.735

Evidence 1 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Hemolysis

Activity Measurement 0.5 µM

Hemolysis Raw

[Ref.8163497]LC50=0.5 µM against human erythrocytes

Target

RBC Target human erythrocytes

Source & Reference

Database Source APD_complete APD_hemolytic

Source DRAMP4

Reference

J Biol Chem. 1994 Apr 22 269(16):11956-11961.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 0.5 µM

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.8163497]LC50=0.5 µM against human erythrocytes

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

J Biol Chem. 1994 Apr 22 269(16):11956-11961.

Evidence 3 Hemolysis

Activity

Activity Measurement 0.5 µM

Activity Endpoint LC50

Hemolysis Raw

[Ref.8163497]LC50=0.5 µM against human erythrocytes

Detail Source Activity Hemolysis

Target

RBC Target human erythrocytes

Source & Reference

source APD_complete APD_hemolytic

Reference

J Biol Chem. 1994 Apr 22 269(16):11956-11961.

Source DRAMP4

Database Source APD_complete APD_hemolytic