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Peptide record

TPDB13342

MagaininF5W-Lys Antibacterial Anticancer Antiparasitic Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB13342
MagaininF5W-Lys
Antibacterial Anticancer Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and CancerPPD 2.0, with an available 3D structural model.
Sequence
GIGKWLHSAKKFGKAFVGEIMNS
Physicochemical Analysis
C116H181N31O29S1
RDCQPTY
GK
2505.96
10.55
5
1
10
+3
1.87
-0.078
72.17
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
219.48
3
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
1
E
0
Q
4
G
1
H
2
I
1
L
4
K
1
M
2
F
0
P
2
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 4 H: 1 I: 2 L: 1 K: 4 M: 1 F: 2 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
23
C116H181N31O29S1
2505.96
10.55
+3
1.87
-0.078
Free
L
Linear
Free
Antimicrobial
Synthetic
Evidence Records 6 records
Evidence 1 Activity

Activity

IC50
IC50 = 16.8 µM
Anticancer
16.8 µM

Target

Blood Cancer
Jurkat
Blood

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2020

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

2.8% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
2.8% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Conjugation of Cell-Penetrating Peptides to Antimicrobial Peptides Enhances Antibacterial Activity. | ACS Omega | 2019
Evidence 3 Activity

Activity

97% Killing
Toxicity
100 µM
Cytotoxic
97% Killing | 100 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Improvement of Therapeutic Index by the Combination of Enhanced Peptide Cationicity and Proline Introduction. | ACS Infect Dis | 2020
Evidence 4 Activity

Activity

92% Killing
Toxicity
100 µM
Cytotoxic
92% Killing | 100 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Improvement of Therapeutic Index by the Combination of Enhanced Peptide Cationicity and Proline Introduction. | ACS Infect Dis | 2020
Evidence 5 Activity

Activity

IC50
Toxicity
>=65 µM
Cytotoxic
IC50 | >=65 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. | Biochim Biophys Acta | 2020
Evidence 6 Activity

Activity

IC50
Toxicity
65 µM
Hemolytic Cytotoxic
Hemolytic_activity: RBC: IC50 ≥ 65 µM | Cytotoxicity: PBMC: IC50 ≥ 65 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta Biomembr. 2020 Aug 1 1862(8):183228.