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Peptide record

TPDB13341

Antibacterial Toxicity standard

23 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB13341

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

RIIDRLWRVRRPQKPKFVTVWVR

FASTA

>TPDB13341|Antibacterial;Toxicity|length=23
RIIDRLWRVRRPQKPKFVTVWVR

Formula C140H230N46O28

Absent Amino Acids ANCEGHMSY

Common Amino Acids R

Mass 3005.66

PI 12.71

Basic Residues 8

Acidic Residues 1

Hydrophobic Residues 10

Net Charge +7

Boman Index 3.96

Hydrophobicity -0.657

Aliphatic Index 101.30

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 11000

Absorbance 280nm 365.98

Polar Residues 2

number

Amino Acid Distribution

A: 0 R: 6 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 1 K: 2 M: 0 F: 1 P: 2 S: 0 T: 1 W: 2 Y: 0 V: 4

Length

Formula

C140H230N46O28

Mass

3005.66

12.71

Net Charge

Boman Index

3.96

Hydrophobicity

-0.657

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.025 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus ATCC 25923 (MIC 0.025 ug/ml), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC 21533 (MIC 125 ug/ml), B. subti

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism Staphylococcus epidermidis LY8

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus ATCC 25923 (MIC 0.025 ug/ml), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC 21533 (MIC 125 ug/ml), B. subtilis CICC 24434 (MIC 1.56 ug/ml), S.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 125 µg/mL

Target

Target Organism L. monocytogenes CICC 21533

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus ATCC 25923 (MIC 0.025 ug/ml), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC 21533 (MIC 125 ug/ml), B. subtilis CICC 24434 (MIC 1.56 ug/ml), S. enterica serovar Choleraesuis C78-1 or serov

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µg/mL

Target

Target Organism B. subtilis CICC 24434

Source & Reference

Database Source NA

Other

Evidence Text

5 ug/ml), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC 21533 (MIC 125 ug/ml), B. subtilis CICC 24434 (MIC 1.56 ug/ml), S. enterica serovar Choleraesuis C78-1 or serovar Typhimurium SL1344 (MIC 0.78-1.56 ug/m

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.78-1.56 µg/mL

Target

Target Organism S. enterica serovar Choleraesuis C78-1 or serovar Typhimurium SL1344

Source & Reference

Database Source NA

Other

Evidence Text

l), L. monocytogenes CICC 21533 (MIC 125 ug/ml), B. subtilis CICC 24434 (MIC 1.56 ug/ml), S. enterica serovar Choleraesuis C78-1 or serovar Typhimurium SL1344 (MIC 0.78-1.56 ug/ml), P. multocida C48-3 (MIC 1.56 ug/ml), enterotoxigenic E. coli E44813 (MIC 12.5 ug/ml), an

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µg/mL

Target

Target Organism P. multocida C48-3

Source & Reference

Database Source NA

Other

Evidence Text

enterica serovar Choleraesuis C78-1 or serovar Typhimurium SL1344 (MIC 0.78-1.56 ug/ml), P. multocida C48-3 (MIC 1.56 ug/ml), enterotoxigenic E. coli E44813 (MIC 12.5 ug/ml), and S. flexneri CICC 21534 (MIC 75 ug/m

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µg/mL

Target

Target Organism Escherichia coli E44813

Source & Reference

Database Source NA

Other

Evidence Text

murium SL1344 (MIC 0.78-1.56 ug/ml), P. multocida C48-3 (MIC 1.56 ug/ml), enterotoxigenic E. coli E44813 (MIC 12.5 ug/ml), and S. flexneri CICC 21534 (MIC 75 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 µg/mL

Target

Target Organism S. flexneri CICC 21534

Source & Reference

Database Source NA

Other

Evidence Text

P. multocida C48-3 (MIC 1.56 ug/ml), enterotoxigenic E. coli E44813 (MIC 12.5 ug/ml), and S. flexneri CICC 21534 (MIC 75 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint <4% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 1000 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

<4% Hemolysis | 1000 | µg/mL | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Analogs of the Cathelicidin-Derived Antimicrobial Peptide PMAP-23 Exhibit Improved Stability and Antibacterial Activity. | Probiotics Antimicrob Proteins | 2020

Evidence 10 Activity

Activity

Activity Endpoint <10% Killing

Detail Source Activity Toxicity

Activity Measurement 500 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

<10% Killing | 500 | µg/mL | target cell: Mouse fibroblasts NIH 3T3

Target

Target Cell Mouse fibroblasts NIH 3T3

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Analogs of the Cathelicidin-Derived Antimicrobial Peptide PMAP-23 Exhibit Improved Stability and Antibacterial Activity. | Probiotics Antimicrob Proteins | 2020