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Peptide record

TPDB13338

Antibacterial Anticancer Antifungal Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB13338
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb iACP-DRLF CAFPdb dbAMP
standard
No
A 22-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.
Sequence
FAKLWAKLAFGKGIGKVGKKLL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C117H193N29O23
RNDCEQHMPSTY
K
2374.00
11.21
6
0
12
+6
-0.58
0.409
115.45
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
2.32
0
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
1
I
4
L
6
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 1 L: 4 K: 6 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
22 reviewed residue count
C117H193N29O23 sequence-only estimate (linear, free termini)
2374.00 sequence-only estimate (linear, free termini)
11.21 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
-0.58 sequence-only estimate (linear, free termini)
0.409 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

LD50
Toxicity
110 µg/mL
Cytotoxic
LD50 | 110 | µg/mL | target cell: Human fibroblasts WI-38

Target

Human fibroblasts WI-38

Source & Reference

NA
DBAASP
Short bioactive peptides | PATENT US 6875744B2 | 2005
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
900 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 900 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short bioactive peptides | PATENT US 6875744B2 | 2005