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Peptide record

TPDB13328

Antibacterial Antifungal Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB13328
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
FFRHIVGAISRIFGQKQRDMAD
Physicochemical Analysis
C116H182N36O30S1
NCELPTWY
RIF
2593.00
11.22
5
2
10
+2
3.33
-0.209
75.45
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
2
A
3
R
0
N
2
D
0
C
0
E
2
Q
2
G
1
H
3
I
0
L
1
K
1
M
3
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 2 C: 0 E: 0 Q: 2 G: 2 H: 1 I: 3 L: 0 K: 1 M: 1 F: 3 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
22
C116H182N36O30S1
2593.00
11.22
+2
3.33
-0.209
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5-25 µM

Target

B. cereus

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ bacteria B. cereus (MIC 12.5-25 uM), B. subtilis (MIC 6.25-12.5 uM), S. aureus 3.1-6.2 uM), C. glutamicum (MIC 1.6-3.2 uM), S
Evidence 2 Activity

Activity

MIC
Antibacterial
6.25-12.5 µM

Target

B. subtilis

Source & Reference

dbAMP

Other

Active against Gram+ bacteria B. cereus (MIC 12.5-25 uM), B. subtilis (MIC 6.25-12.5 uM), S. aureus 3.1-6.2 uM), C. glutamicum (MIC 1.6-3.2 uM), S. epidermidis (MIC 12.5-25 uM),
Evidence 3 Activity

Activity

MIC
Antibacterial
1.6-3.2 µM

Target

C. glutamicum

Source & Reference

dbAMP

Other

cteria B. cereus (MIC 12.5-25 uM), B. subtilis (MIC 6.25-12.5 uM), S. aureus 3.1-6.2 uM), C. glutamicum (MIC 1.6-3.2 uM), S. epidermidis (MIC 12.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluores
Evidence 4 Activity

Activity

MIC
Antibacterial
12.5-25 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP

Other

), B. subtilis (MIC 6.25-12.5 uM), S. aureus 3.1-6.2 uM), C. glutamicum (MIC 1.6-3.2 uM), S. epidermidis (MIC 12.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluorescens (MIC 6.25-12.5 uM), P. stutz
Evidence 5 Activity

Activity

MIC
Antibacterial
25-50 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

-6.2 uM), C. glutamicum (MIC 1.6-3.2 uM), S. epidermidis (MIC 12.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluorescens (MIC 6.25-12.5 uM), P. stutzeri (MIC 3.1-6.25 uM), A-hydrophila (MIC>50 u
Evidence 6 Activity

Activity

MIC
Antibacterial
6.25-12.5 µM

Target

Pseudomonas fluorescens

Source & Reference

dbAMP

Other

.6-3.2 uM), S. epidermidis (MIC 12.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluorescens (MIC 6.25-12.5 uM), P. stutzeri (MIC 3.1-6.25 uM), A-hydrophila (MIC>50 uM), E. coli (MIC 12.5-25 uM), S. fl
Evidence 7 Activity

Activity

MIC
Antibacterial
3.1-6.25 µM

Target

Pseudomonas stutzeri

Source & Reference

dbAMP

Other

5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluorescens (MIC 6.25-12.5 uM), P. stutzeri (MIC 3.1-6.25 uM), A-hydrophila (MIC>50 uM), E. coli (MIC 12.5-25 uM), S. flexneri (MIC 6.2-12.5 uM), V-par
Evidence 8 Activity

Activity

MIC
Antibacterial
12.5-25 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

fluorescens (MIC 6.25-12.5 uM), P. stutzeri (MIC 3.1-6.25 uM), A-hydrophila (MIC>50 uM), E. coli (MIC 12.5-25 uM), S. flexneri (MIC 6.2-12.5 uM), V-parahaemolyticus, V-alginolyticus (MIC>50 uM), fungi C.
Evidence 9 Activity

Activity

MIC
Antibacterial
6.2-12.5 µM

Target

S. flexneri

Source & Reference

dbAMP

Other

5 uM), P. stutzeri (MIC 3.1-6.25 uM), A-hydrophila (MIC>50 uM), E. coli (MIC 12.5-25 uM), S. flexneri (MIC 6.2-12.5 uM), V-parahaemolyticus, V-alginolyticus (MIC>50 uM), fungi C. albicans (MIC 12.5-25 uM), and
Evidence 10 Activity

Activity

MIC
Antibacterial
12.5-25 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

M), S. flexneri (MIC 6.2-12.5 uM), V-parahaemolyticus, V-alginolyticus (MIC>50 uM), fungi C. albicans (MIC 12.5-25 uM), and C. neoformans (MIC 1.56-3.12 uM). LPS stimulation led to relatively constant express
Evidence 11 Activity

Activity

MIC
Antibacterial
1.56-3.12 µM

Target

C. neoformans

Source & Reference

dbAMP

Other

V-parahaemolyticus, V-alginolyticus (MIC>50 uM), fungi C. albicans (MIC 12.5-25 uM), and C. neoformans (MIC 1.56-3.12 uM). LPS stimulation led to relatively constant expression with time in 48 h. Updated Jan2020
Evidence 12 Activity

Activity

MIC
Antifungal
12.5-25 µM

Target

B. cereus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ bacteria B. cereus (MIC 12.5-25 uM), B. subtilis (MIC 6.25-12.5 uM), S. aureus 3.1-6.2 uM), C. glutamicum (MIC 1.6-3.2 uM), S
Evidence 13 Activity

Activity

MIC
Antifungal
6.25-12.5 µM

Target

B. subtilis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ bacteria B. cereus (MIC 12.5-25 uM), B. subtilis (MIC 6.25-12.5 uM), S. aureus 3.1-6.2 uM), C. glutamicum (MIC 1.6-3.2 uM), S. epidermidis (MIC 12.5-25 uM),
Evidence 14 Activity

Activity

MIC
Antifungal
1.6-3.2 µM

Target

C. glutamicum

Source & Reference

dbAMP CAFPdb Antifungipept

Other

cteria B. cereus (MIC 12.5-25 uM), B. subtilis (MIC 6.25-12.5 uM), S. aureus 3.1-6.2 uM), C. glutamicum (MIC 1.6-3.2 uM), S. epidermidis (MIC 12.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluores
Evidence 15 Activity

Activity

MIC
Antifungal
12.5-25 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

), B. subtilis (MIC 6.25-12.5 uM), S. aureus 3.1-6.2 uM), C. glutamicum (MIC 1.6-3.2 uM), S. epidermidis (MIC 12.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluorescens (MIC 6.25-12.5 uM), P. stutz
Evidence 16 Activity

Activity

MIC
Antifungal
25-50 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

-6.2 uM), C. glutamicum (MIC 1.6-3.2 uM), S. epidermidis (MIC 12.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluorescens (MIC 6.25-12.5 uM), P. stutzeri (MIC 3.1-6.25 uM), A-hydrophila (MIC>50 u
Evidence 17 Activity

Activity

MIC
Antifungal
6.25-12.5 µM

Target

Pseudomonas fluorescens

Source & Reference

dbAMP CAFPdb Antifungipept

Other

.6-3.2 uM), S. epidermidis (MIC 12.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluorescens (MIC 6.25-12.5 uM), P. stutzeri (MIC 3.1-6.25 uM), A-hydrophila (MIC>50 uM), E. coli (MIC 12.5-25 uM), S. fl
Evidence 18 Activity

Activity

MIC
Antifungal
3.1-6.25 µM

Target

Pseudomonas stutzeri

Source & Reference

dbAMP CAFPdb Antifungipept

Other

5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluorescens (MIC 6.25-12.5 uM), P. stutzeri (MIC 3.1-6.25 uM), A-hydrophila (MIC>50 uM), E. coli (MIC 12.5-25 uM), S. flexneri (MIC 6.2-12.5 uM), V-par
Evidence 19 Activity

Activity

MIC
Antifungal
12.5-25 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

fluorescens (MIC 6.25-12.5 uM), P. stutzeri (MIC 3.1-6.25 uM), A-hydrophila (MIC>50 uM), E. coli (MIC 12.5-25 uM), S. flexneri (MIC 6.2-12.5 uM), V-parahaemolyticus, V-alginolyticus (MIC>50 uM), fungi C.
Evidence 20 Activity

Activity

MIC
Antifungal
6.2-12.5 µM

Target

S. flexneri

Source & Reference

dbAMP CAFPdb Antifungipept

Other

5 uM), P. stutzeri (MIC 3.1-6.25 uM), A-hydrophila (MIC>50 uM), E. coli (MIC 12.5-25 uM), S. flexneri (MIC 6.2-12.5 uM), V-parahaemolyticus, V-alginolyticus (MIC>50 uM), fungi C. albicans (MIC 12.5-25 uM), and
Evidence 21 Activity

Activity

MIC
Antifungal
12.5-25 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

M), S. flexneri (MIC 6.2-12.5 uM), V-parahaemolyticus, V-alginolyticus (MIC>50 uM), fungi C. albicans (MIC 12.5-25 uM), and C. neoformans (MIC 1.56-3.12 uM). LPS stimulation led to relatively constant express
Evidence 22 Activity

Activity

MIC
Antifungal
1.56-3.12 µM

Target

C. neoformans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

V-parahaemolyticus, V-alginolyticus (MIC>50 uM), fungi C. albicans (MIC 12.5-25 uM), and C. neoformans (MIC 1.56-3.12 uM). LPS stimulation led to relatively constant expression with time in 48 h. Updated Jan2020
Evidence 23 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Mouse hepatocytes AML12

Target

Mouse hepatocytes AML12

Source & Reference

NA
DBAASP
Antimicrobial activity and mechanisms of multiple antimicrobial peptides isolated from rockfish Sebastiscus marmoratus. | Fish Shellfish Immunol | 2019