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Peptide record

TPDB13326

Antibacterial Anticancer Hemolysis Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB13326
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
RRWCVYAYVRVRGVRVYAYVCW
Physicochemical Analysis
C132H195N39O27S2
NDEQHILKMFPST
V
2824.37
10.18
5
0
14
+5
-3.80
0.177
88.18
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
17085
604.91
6
Residue Composition
number
2
A
5
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
4
Y
6
V
Amino Acid Distribution
A: 2 R: 5 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 4 V: 6
Chemical Descriptors
22
C132H195N39O27S2
2824.37
10.18
+5
-3.80
0.177
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
16->16 µM

Target

E.coli ML35p or ATCC 25922 or M15

Source & Reference

NA

Other

active against Gram- E.coli ML35p or ATCC 25922 or M15 (MIC 16->16 uM), P-aeruginosa ATCC 27853 or clinical c.i. (MIC >16 uM), A-baumanii c.i. (MIC >16 uM), Gra
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

L. monocytogenes EGD

Source & Reference

NA

Other

-aeruginosa ATCC 27853 or clinical c.i. (MIC >16 uM), A-baumanii c.i. (MIC >16 uM), Gram+ L. monocytogenes EGD (MIC 8 uM), S-aureus 710A or ATCC 25923 or MRSA ATCC 33591 or clinical c.i. (MIC >16 uM), S-intermid
Evidence 3 Activity

Activity

15% Hemolysis
Toxicity
23.5 µM
Hemolytic Cytotoxic
15% Hemolysis | 23.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Redesigning Arenicin-1, an Antimicrobial Peptide from the Marine Polychaeta Arenicola marina, by Strand Rearrangement or Branching, Substitution of Specific Residues, and Backbone Linearization or Cyclization. | Mar Drugs | 2019
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
>80 µM
Hemolytic Cytotoxic
50% Hemolysis | >80 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Redesigning Arenicin-1, an Antimicrobial Peptide from the Marine Polychaeta Arenicola marina, by Strand Rearrangement or Branching, Substitution of Specific Residues, and Backbone Linearization or Cyclization. | Mar Drugs | 2019
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Mar Drugs. 2019 Jun 23 17(6):376.
Evidence 6 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis