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Peptide record

TPDB13316

Antibacterial Anticancer Antifungal Antiparasitic standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB13316
Antibacterial Anticancer Antifungal Antiparasitic
Anti-infective peptides Cancer-related peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 22-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLWEKIKEKANELVSGIVEGVK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C110H184N28O33
RDCQHMFPTY
EK
2426.84
7.17
4
4
9
+0
0.94
-0.227
115.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
2.27
2
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
4
E
0
Q
3
G
0
H
2
I
2
L
4
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 4 Q: 0 G: 3 H: 0 I: 2 L: 2 K: 4 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 3
Chemical Descriptors
22 reviewed residue count
C110H184N28O33 sequence-only estimate (linear, free termini)
2426.84 sequence-only estimate (linear, free termini)
7.17 sequence-only estimate (linear, free termini)
+0 sequence-only estimate (linear, free termini)
0.94 sequence-only estimate (linear, free termini)
-0.227 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Activity against M. luteus (MIC 3ug/ml) and E. coli (MIC 25ug/ml). It might have an alpha helix conformation. Updated 4/2019.
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Activity against M. luteus (MIC 3ug/ml) and E. coli (MIC 25ug/ml). It might have an alpha helix conformation. Updated 4/2019.
Evidence 3 Activity

Activity

MIC
Antifungal
3 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Activity against M. luteus (MIC 3ug/ml) and E. coli (MIC 25ug/ml). It might have an alpha helix conformation. Updated 4/2019.
Evidence 4 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Activity against M. luteus (MIC 3ug/ml) and E. coli (MIC 25ug/ml). It might have an alpha helix conformation. Updated 4/2019.
Evidence 5 Activity

Activity

MIC
Antiparasitic
3 µg/mL

Target

M. luteus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Activity against M. luteus (MIC 3ug/ml) and E. coli (MIC 25ug/ml). It might have an alpha helix conformation. Updated 4/2019.
Evidence 6 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

Activity against M. luteus (MIC 3ug/ml) and E. coli (MIC 25ug/ml). It might have an alpha helix conformation. Updated 4/2019.