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Peptide record

TPDB13305

Antibacterial Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB13305
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IHHIHHIIHHIHHIIHHIHHI
Physicochemical Analysis
C126H185N45O22
ARNDCEQGLKMFPSTWYV
H
2682.14
8.39
12
0
9
+1
8.73
0.100
167.14
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
12
H
9
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 12 I: 9 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C126H185N45O22
2682.14
8.39
+1
8.73
0.100
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
10% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Highly Stabilized ?-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition. | ACS Appl Mater Interfaces | 2019
Evidence 2 Activity

Activity

10% Killing
Toxicity
>128 µM
Cytotoxic
10% Killing | >128 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Highly Stabilized ?-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition. | ACS Appl Mater Interfaces | 2019
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
5 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31199117] 5% hemolysis at 63µM, 8% hemolysis at 128µM against human red blood cells | Cytotoxicity: [Ref.31199117] ①The cell viability of HEK293T cells induced by 3IH3 is 103.6%, 102.2%, 102.8%, 105%, 103.1%, 104.2% and 105.8% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 µM at pH 7.4, while that induced by Melittin is 47.2%, 1.7%, 1.9%, 0.6%, 0.6%, 0.6% and 1.7% at 2, 4, 8, 16, 32, 64 and 128 µM. ②The cell viability of HEK293T cells induced by 3IH3 is 103.9%, 103.1%, 103.9%, 102.2%, 104.2%, 103.1% and 101.7% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 µM at pH 6.0, while that induced by Melittin is 43.8%, 3.4%, 3.4%, 0%, 2.2%, 0% and 1.1% at 2, 4, 8, 16, 32, 64 and 128 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Appl Mater Interfaces. 2019 Jun 26 11(25):22113-22128. doi: 10.1021/acsami.9b04654. Epub 2019 Jun 14.