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Peptide record

TPDB13300

Antibacterial Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB13300
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 21-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KEKLKLKCKAPKCYNDKLACT
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C106H185N29O29S3
RQGHIMFSWV
K
2425.99
9.81
7
2
6
+5
1.98
-0.900
65.24
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1615
0.67
6
Residue Composition
number
2
A
0
R
1
N
1
D
3
C
1
E
0
Q
0
G
0
H
0
I
3
L
7
K
0
M
0
F
1
P
0
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 3 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 7 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
21 reviewed residue count
C106H185N29O29S3 sequence-only estimate (linear, free termini)
2425.99 sequence-only estimate (linear, free termini)
9.81 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
1.98 sequence-only estimate (linear, free termini)
-0.900 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. | J Proteome Res | 2012
Evidence 2 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:22029824]Non-hemolytic activity against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Proteome Res. 2012 Jan 1 11(1):306-319.